Human Gene CADM4 (ENST00000222374.3) from GENCODE V44
  Description: Homo sapiens cell adhesion molecule 4 (CADM4), mRNA. (from RefSeq NM_145296)
Gencode Transcript: ENST00000222374.3
Gencode Gene: ENSG00000105767.3
Transcript (Including UTRs)
   Position: hg38 chr19:43,622,368-43,639,850 Size: 17,483 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr19:43,623,330-43,639,790 Size: 16,461 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:43,622,368-43,639,850)mRNA (may differ from genome)Protein (388 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CADM4_HUMAN
DESCRIPTION: RecName: Full=Cell adhesion molecule 4; AltName: Full=Immunoglobulin superfamily member 4C; Short=IgSF4C; AltName: Full=Nectin-like protein 4; Short=NECL-4; AltName: Full=TSLC1-like protein 2; Flags: Precursor;
FUNCTION: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity.
SUBUNIT: Monomer and homodimer.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in brain, prostate, brain, kidney and some other organs.
PTM: N-glycosylated (By similarity).
SIMILARITY: Belongs to the nectin family.
SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SEQUENCE CAUTION: Sequence=AAC32740.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CADM4
Diseases sorted by gene-association score: renal clear cell carcinoma (3), cleft lip/palate-ectodermal dysplasia syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 122.03 RPKM in Nerve - Tibial
Total median expression: 1364.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.0060-0.533 Picture PostScript Text
3' UTR -414.80962-0.431 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013162 - CD80_C2-set
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR013106 - Ig_V-set
IPR003585 - Neurexin-like

Pfam Domains:
PF08205 - CD80-like C2-set immunoglobulin domain
PF07686 - Immunoglobulin V-set domain

ModBase Predicted Comparative 3D Structure on Q8NFZ8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0042803 protein homodimerization activity
GO:0050839 cell adhesion molecule binding

Biological Process:
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0008037 cell recognition

Cellular Component:
GO:0005887 integral component of plasma membrane
GO:0005913 cell-cell adherens junction
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC068457 - Homo sapiens cell adhesion molecule 4, mRNA (cDNA clone IMAGE:4375136).
AF363368 - Homo sapiens TSLC1-like 2 (TSLL2) mRNA, complete cds.
JD485939 - Sequence 466963 from Patent EP1572962.
JD057941 - Sequence 38965 from Patent EP1572962.
JD224584 - Sequence 205608 from Patent EP1572962.
JD464397 - Sequence 445421 from Patent EP1572962.
JD278434 - Sequence 259458 from Patent EP1572962.
JD555881 - Sequence 536905 from Patent EP1572962.
JD500446 - Sequence 481470 from Patent EP1572962.
JD404174 - Sequence 385198 from Patent EP1572962.
JD375647 - Sequence 356671 from Patent EP1572962.
JD327629 - Sequence 308653 from Patent EP1572962.
JD113944 - Sequence 94968 from Patent EP1572962.
JD130553 - Sequence 111577 from Patent EP1572962.
JD475350 - Sequence 456374 from Patent EP1572962.
JD369027 - Sequence 350051 from Patent EP1572962.
JD382097 - Sequence 363121 from Patent EP1572962.
JD209940 - Sequence 190964 from Patent EP1572962.
JD364433 - Sequence 345457 from Patent EP1572962.
BC113963 - Homo sapiens cell adhesion molecule 4, mRNA (cDNA clone IMAGE:40023999), partial cds.
JD065422 - Sequence 46446 from Patent EP1572962.
AK313028 - Homo sapiens cDNA, FLJ93498, Homo sapiens TSLC1-like 2 (TSLL2), mRNA.
BC140326 - Synthetic construct Homo sapiens clone IMAGE:100014379, MGC:173232 cell adhesion molecule 4 (CADM4) mRNA, encodes complete protein.
BC141627 - Synthetic construct Homo sapiens clone IMAGE:100014610, MGC:175324 cell adhesion molecule 4 (CADM4) mRNA, encodes complete protein.
AB528095 - Synthetic construct DNA, clone: pF1KB7234, Homo sapiens CADM4 gene for cell adhesion molecule 4, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R7L5, CADM4_HUMAN, ENST00000222374.1, ENST00000222374.2, IGSF4C, NECL4, NM_145296, Q8NFZ8, Q9Y4A4, TSLL2, uc002oxc.1, uc002oxc.2, uc002oxc.3
UCSC ID: ENST00000222374.3
RefSeq Accession: NM_145296
Protein: Q8NFZ8 (aka CADM4_HUMAN)
CCDS: CCDS12627.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.