ID:CADM4_HUMAN DESCRIPTION: RecName: Full=Cell adhesion molecule 4; AltName: Full=Immunoglobulin superfamily member 4C; Short=IgSF4C; AltName: Full=Nectin-like protein 4; Short=NECL-4; AltName: Full=TSLC1-like protein 2; Flags: Precursor; FUNCTION: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity. SUBUNIT: Monomer and homodimer. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Expressed in brain, prostate, brain, kidney and some other organs. PTM: N-glycosylated (By similarity). SIMILARITY: Belongs to the nectin family. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SEQUENCE CAUTION: Sequence=AAC32740.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NFZ8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Cellular Component: GO:0005887 integral component of plasma membrane GO:0005913 cell-cell adherens junction GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
BC068457 - Homo sapiens cell adhesion molecule 4, mRNA (cDNA clone IMAGE:4375136). AF363368 - Homo sapiens TSLC1-like 2 (TSLL2) mRNA, complete cds. JD485939 - Sequence 466963 from Patent EP1572962. JD057941 - Sequence 38965 from Patent EP1572962. JD224584 - Sequence 205608 from Patent EP1572962. JD464397 - Sequence 445421 from Patent EP1572962. JD278434 - Sequence 259458 from Patent EP1572962. JD555881 - Sequence 536905 from Patent EP1572962. JD500446 - Sequence 481470 from Patent EP1572962. JD404174 - Sequence 385198 from Patent EP1572962. JD375647 - Sequence 356671 from Patent EP1572962. JD327629 - Sequence 308653 from Patent EP1572962. JD113944 - Sequence 94968 from Patent EP1572962. JD130553 - Sequence 111577 from Patent EP1572962. JD475350 - Sequence 456374 from Patent EP1572962. JD369027 - Sequence 350051 from Patent EP1572962. JD382097 - Sequence 363121 from Patent EP1572962. JD209940 - Sequence 190964 from Patent EP1572962. JD364433 - Sequence 345457 from Patent EP1572962. BC113963 - Homo sapiens cell adhesion molecule 4, mRNA (cDNA clone IMAGE:40023999), partial cds. JD065422 - Sequence 46446 from Patent EP1572962. AK313028 - Homo sapiens cDNA, FLJ93498, Homo sapiens TSLC1-like 2 (TSLL2), mRNA. BC140326 - Synthetic construct Homo sapiens clone IMAGE:100014379, MGC:173232 cell adhesion molecule 4 (CADM4) mRNA, encodes complete protein. BC141627 - Synthetic construct Homo sapiens clone IMAGE:100014610, MGC:175324 cell adhesion molecule 4 (CADM4) mRNA, encodes complete protein. AB528095 - Synthetic construct DNA, clone: pF1KB7234, Homo sapiens CADM4 gene for cell adhesion molecule 4, without stop codon, in Flexi system.