Human Gene IRGC (ENST00000244314.6) from GENCODE V44
  Description: Homo sapiens immunity related GTPase cinema (IRGC), mRNA. (from RefSeq NM_019612)
Gencode Transcript: ENST00000244314.6
Gencode Gene: ENSG00000124449.7
Transcript (Including UTRs)
   Position: hg38 chr19:43,716,076-43,720,021 Size: 3,946 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr19:43,718,559-43,719,950 Size: 1,392 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:43,716,076-43,720,021)mRNA (may differ from genome)Protein (463 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IIGP5_HUMAN
DESCRIPTION: RecName: Full=Interferon-inducible GTPase 5; EC=3.6.5.-; AltName: Full=Immunity-related GTPase cinema 1;
CATALYTIC ACTIVITY: GTP + H(2)O = GDP + phosphate.
SIMILARITY: Belongs to the interferon-inducible GTPase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IRGC
Diseases sorted by gene-association score: solar retinopathy (3), echolalia (2), factitious disorder (2), multiple personality disorder (2), asthenopia (2), chorioretinal scar (2), medullomyoblastoma (1), osteosclerotic myeloma (1)

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 149.33 RPKM in Testis
Total median expression: 150.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.80133-0.465 Picture PostScript Text
3' UTR -7.3071-0.103 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007743 - Interferon-induced_GTPase

Pfam Domains:
PF05049 - Interferon-inducible GTPase (IIGP)

ModBase Predicted Comparative 3D Structure on Q6NXR0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein SequenceProtein Sequence Protein Sequence 
AlignmentAlignmentAlignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity

Cellular Component:
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BC033853 - Homo sapiens immunity-related GTPase family, cinema, mRNA (cDNA clone IMAGE:5165357), partial cds.
BC066939 - Homo sapiens immunity-related GTPase family, cinema, mRNA (cDNA clone MGC:87288 IMAGE:4826064), complete cds.
AB464590 - Synthetic construct DNA, clone: pF1KB8837, Homo sapiens IRGC gene for immunity-related GTPase family, cinema, without stop codon, in Flexi system.
KJ894323 - Synthetic construct Homo sapiens clone ccsbBroadEn_03717 IRGC gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000244314.1, ENST00000244314.2, ENST00000244314.3, ENST00000244314.4, ENST00000244314.5, IIGP5, IIGP5_HUMAN, IRGC1, NM_019612, Q05BR8, Q6NXR0, uc002oxh.1, uc002oxh.2, uc002oxh.3, uc002oxh.4, uc002oxh.5
UCSC ID: ENST00000244314.6
RefSeq Accession: NM_019612
Protein: Q6NXR0 (aka IIGP5_HUMAN)
CCDS: CCDS12629.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.