Human Gene KCNJ14 (ENST00000342291.3) from GENCODE V44
  Description: Homo sapiens potassium inwardly rectifying channel subfamily J member 14 (KCNJ14), mRNA. (from RefSeq NM_013348)
RefSeq Summary (NM_013348): Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000342291.3
Gencode Gene: ENSG00000182324.7
Transcript (Including UTRs)
   Position: hg38 chr19:48,455,574-48,466,980 Size: 11,407 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr19:48,461,725-48,464,777 Size: 3,053 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:48,455,574-48,466,980)mRNA (may differ from genome)Protein (436 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IRK14_HUMAN
DESCRIPTION: RecName: Full=ATP-sensitive inward rectifier potassium channel 14; AltName: Full=Inward rectifier K(+) channel Kir2.4; Short=IRK-4; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 14;
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed preferentially in retina.
SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.

-  Primer design for this transcript
 

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.85 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 18.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -151.70340-0.446 Picture PostScript Text
3' UTR -788.702203-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014756 - Ig_E-set
IPR016449 - K_chnl_inward-rec_Kir
IPR013518 - K_chnl_inward-rec_Kir_cyto

Pfam Domains:
PF01007 - Inward rectifier potassium channel

ModBase Predicted Comparative 3D Structure on Q9UNX9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005242 inward rectifier potassium channel activity
GO:0005244 voltage-gated ion channel activity

Biological Process:
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0010107 potassium ion import
GO:0034765 regulation of ion transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body


-  Descriptions from all associated GenBank mRNAs
  AB075822 - Homo sapiens mRNA for KIAA1942 protein.
BC032682 - Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 14, mRNA (cDNA clone IMAGE:5584820), with apparent retained intron.
AF081466 - Homo sapiens inward rectifier potassium channel (KIR2.4) mRNA, complete cds.
JD230471 - Sequence 211495 from Patent EP1572962.
JD190339 - Sequence 171363 from Patent EP1572962.
JD485087 - Sequence 466111 from Patent EP1572962.
JD093931 - Sequence 74955 from Patent EP1572962.
JD522594 - Sequence 503618 from Patent EP1572962.
JD439353 - Sequence 420377 from Patent EP1572962.
JD113428 - Sequence 94452 from Patent EP1572962.
JD393144 - Sequence 374168 from Patent EP1572962.
JD355658 - Sequence 336682 from Patent EP1572962.
BC035918 - Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 14, mRNA (cDNA clone MGC:46111 IMAGE:5531571), complete cds.
JD396371 - Sequence 377395 from Patent EP1572962.
JD262376 - Sequence 243400 from Patent EP1572962.
KJ891503 - Synthetic construct Homo sapiens clone ccsbBroadEn_00897 KCNJ14 gene, encodes complete protein.
JD393232 - Sequence 374256 from Patent EP1572962.
JD547226 - Sequence 528250 from Patent EP1572962.
JD449699 - Sequence 430723 from Patent EP1572962.
DQ593476 - Homo sapiens piRNA piR-33588, complete sequence.
JD426458 - Sequence 407482 from Patent EP1572962.
JD119484 - Sequence 100508 from Patent EP1572962.
JD443688 - Sequence 424712 from Patent EP1572962.
JD334268 - Sequence 315292 from Patent EP1572962.
JD278638 - Sequence 259662 from Patent EP1572962.
JD096288 - Sequence 77312 from Patent EP1572962.
JD287007 - Sequence 268031 from Patent EP1572962.
JD501223 - Sequence 482247 from Patent EP1572962.
JD221636 - Sequence 202660 from Patent EP1572962.
JD241522 - Sequence 222546 from Patent EP1572962.
JD328391 - Sequence 309415 from Patent EP1572962.
JD037984 - Sequence 19008 from Patent EP1572962.
JD507671 - Sequence 488695 from Patent EP1572962.
JD361062 - Sequence 342086 from Patent EP1572962.
JD515049 - Sequence 496073 from Patent EP1572962.
JD087643 - Sequence 68667 from Patent EP1572962.
JD317071 - Sequence 298095 from Patent EP1572962.
JD251691 - Sequence 232715 from Patent EP1572962.
JD099486 - Sequence 80510 from Patent EP1572962.
JD420459 - Sequence 401483 from Patent EP1572962.
JD173084 - Sequence 154108 from Patent EP1572962.
JD322758 - Sequence 303782 from Patent EP1572962.
JD539408 - Sequence 520432 from Patent EP1572962.
JD480567 - Sequence 461591 from Patent EP1572962.
JD476789 - Sequence 457813 from Patent EP1572962.
JD414967 - Sequence 395991 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UNX9 (Reactome details) participates in the following event(s):

R-HSA-1296046 KCNJs transport K+ from cytosol to extracellular region
R-HSA-1296053 Classical Kir channels
R-HSA-5576886 Phase 4 - resting membrane potential
R-HSA-1296065 Inwardly rectifying K+ channels
R-HSA-5576891 Cardiac conduction
R-HSA-1296071 Potassium Channels
R-HSA-397014 Muscle contraction
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000342291.1, ENST00000342291.2, IRK14_HUMAN, IRK4, NM_013348, Q9UNX9, uc002pje.1, uc002pje.2, uc002pje.3, uc002pje.4
UCSC ID: ENST00000342291.3
RefSeq Accession: NM_013348
Protein: Q9UNX9 (aka IRK14_HUMAN or IRKE_HUMAN)
CCDS: CCDS12721.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.