Human Gene KCNJ14 (ENST00000342291.3) from GENCODE V44
Description: Homo sapiens potassium inwardly rectifying channel subfamily J member 14 (KCNJ14), mRNA. (from RefSeq NM_013348) RefSeq Summary (NM_013348): Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000342291.3 Gencode Gene: ENSG00000182324.7 Transcript (Including UTRs) Position: hg38 chr19:48,455,574-48,466,980 Size: 11,407 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr19:48,461,725-48,464,777 Size: 3,053 Coding Exon Count: 2
ID:IRK14_HUMAN DESCRIPTION: RecName: Full=ATP-sensitive inward rectifier potassium channel 14; AltName: Full=Inward rectifier K(+) channel Kir2.4; Short=IRK-4; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 14; FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed preferentially in retina. SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UNX9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0010107 potassium ion import GO:0034765 regulation of ion transmembrane transport