Human Gene PRRG2 (ENST00000246794.10) from GENCODE V44
  Description: Homo sapiens proline rich and Gla domain 2 (PRRG2), transcript variant 2, mRNA. (from RefSeq NM_001316335)
RefSeq Summary (NM_000951): The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gencode Transcript: ENST00000246794.10
Gencode Gene: ENSG00000126460.11
Transcript (Including UTRs)
   Position: hg38 chr19:49,581,316-49,591,004 Size: 9,689 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr19:49,583,220-49,590,389 Size: 7,170 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:49,581,316-49,591,004)mRNA (may differ from genome)Protein (202 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMG2_HUMAN
DESCRIPTION: RecName: Full=Transmembrane gamma-carboxyglutamic acid protein 2; AltName: Full=Proline-rich gamma-carboxyglutamic acid protein 2; Short=Proline-rich Gla protein 2; Flags: Precursor;
SUBUNIT: Interacts with NEDD4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Highly expressed in the thyroid.
PTM: Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma- carboxylase.
SIMILARITY: Contains 1 Gla (gamma-carboxy-glutamate) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.98 RPKM in Pituitary
Total median expression: 115.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -72.50179-0.405 Picture PostScript Text
3' UTR -243.20615-0.395 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017857 - Coagulation_fac_subgr_Gla_dom
IPR000294 - GLA_domain

Pfam Domains:
PF00594 - Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

ModBase Predicted Comparative 3D Structure on O14669
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding

Biological Process:
GO:0006508 proteolysis

Cellular Component:
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC026032 - Homo sapiens proline rich Gla (G-carboxyglutamic acid) 2, mRNA (cDNA clone MGC:39251 IMAGE:3960215), complete cds.
AF009243 - Homo sapiens proline-rich Gla protein 2 (PRGP2) mRNA, complete cds.
CR456846 - Homo sapiens full open reading frame cDNA clone RZPDo834H066D for gene PRRG2, proline-rich Gla (G-carboxyglutamic acid) polypeptide 2; complete cds, incl. stopcodon.
AB527706 - Synthetic construct DNA, clone: pF1KB6892, Homo sapiens PRRG2 gene for proline rich Gla (G-carboxyglutamic acid) 2, without stop codon, in Flexi system.
JD050892 - Sequence 31916 from Patent EP1572962.
DQ573218 - Homo sapiens piRNA piR-41330, complete sequence.
JD227252 - Sequence 208276 from Patent EP1572962.
JD401078 - Sequence 382102 from Patent EP1572962.
JD523849 - Sequence 504873 from Patent EP1572962.
JD081231 - Sequence 62255 from Patent EP1572962.
JD188321 - Sequence 169345 from Patent EP1572962.
JD292466 - Sequence 273490 from Patent EP1572962.
JD054091 - Sequence 35115 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000246794.1, ENST00000246794.2, ENST00000246794.3, ENST00000246794.4, ENST00000246794.5, ENST00000246794.6, ENST00000246794.7, ENST00000246794.8, ENST00000246794.9, NM_001316335, O14669, PRGP2, Q6IBF8, TMG2, TMG2_HUMAN, uc002pon.1, uc002pon.2, uc002pon.3, uc002pon.4, uc002pon.5
UCSC ID: ENST00000246794.10
RefSeq Accession: NM_000951
Protein: O14669 (aka TMG2_HUMAN)
CCDS: CCDS12773.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.