Human Gene PRRG2 (ENST00000246794.10) from GENCODE V44
Description: Homo sapiens proline rich and Gla domain 2 (PRRG2), transcript variant 2, mRNA. (from RefSeq NM_001316335) RefSeq Summary (NM_000951): The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]. Gencode Transcript: ENST00000246794.10 Gencode Gene: ENSG00000126460.11 Transcript (Including UTRs) Position: hg38 chr19:49,581,316-49,591,004 Size: 9,689 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr19:49,583,220-49,590,389 Size: 7,170 Coding Exon Count: 6
ID:TMG2_HUMAN DESCRIPTION: RecName: Full=Transmembrane gamma-carboxyglutamic acid protein 2; AltName: Full=Proline-rich gamma-carboxyglutamic acid protein 2; Short=Proline-rich Gla protein 2; Flags: Precursor; SUBUNIT: Interacts with NEDD4 (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Highly expressed in the thyroid. PTM: Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma- carboxylase. SIMILARITY: Contains 1 Gla (gamma-carboxy-glutamate) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14669
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.