Human Gene ATF5 (ENST00000423777.7) Description and Page Index
  Description: Homo sapiens activating transcription factor 5 (ATF5), transcript variant 3, mRNA. (from RefSeq NM_001290746)
Gencode Transcript: ENST00000423777.7
Gencode Gene: ENSG00000169136.11
Transcript (Including UTRs)
   Position: hg38 chr19:49,929,205-49,933,935 Size: 4,731 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr19:49,930,851-49,933,092 Size: 2,242 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:49,929,205-49,933,935)mRNA (may differ from genome)Protein (282 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Cyclic AMP-dependent transcription factor ATF-5; Short=cAMP-dependent transcription factor ATF-5; AltName: Full=Activating transcription factor 5; AltName: Full=Transcription factor ATFx;
FUNCTION: Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.
SUBUNIT: Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34.
INTERACTION: Q9NRI5:DISC1; NbExp=8; IntAct=EBI-492509, EBI-529989;
PTM: Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.
SIMILARITY: Belongs to the bZIP family.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: ATF5
Diseases sorted by gene-association score: triple-receptor negative breast cancer (16)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 784.58 RPKM in Liver
Total median expression: 1417.25 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -82.40315-0.262 Picture PostScript Text
3' UTR -292.90843-0.347 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP

Pfam Domains:
PF00170 - bZIP transcription factor

ModBase Predicted Comparative 3D Structure on Q9Y2D1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0019900 kinase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007623 circadian rhythm
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0021889 olfactory bulb interneuron differentiation
GO:0021891 olfactory bulb interneuron development
GO:0021930 cerebellar granule cell precursor proliferation
GO:0021988 olfactory lobe development
GO:0035264 multicellular organism growth
GO:0043066 negative regulation of apoptotic process
GO:0045444 fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046605 regulation of centrosome cycle
GO:1902750 negative regulation of cell cycle G2/M phase transition

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton

-  Descriptions from all associated GenBank mRNAs
  AK290592 - Homo sapiens cDNA FLJ77831 complete cds, highly similar to Homo sapiens mRNA for leucine-zipper protein.
AK091985 - Homo sapiens cDNA FLJ34666 fis, clone LIVER2000682.
AK024402 - Homo sapiens cDNA FLJ14340 fis, clone SKNMC1000091, highly similar to Cyclic AMP-dependent transcription factor ATF-5.
AB021663 - Homo sapiens mRNA for leucine-zipper protein, complete cds.
AB073613 - Homo sapiens primary hepatoblastoma mRNA for activating transcription factor 5, partial cds, clone:HMFN0395.
JD136524 - Sequence 117548 from Patent EP1572962.
JD161388 - Sequence 142412 from Patent EP1572962.
JD547422 - Sequence 528446 from Patent EP1572962.
BC005174 - Homo sapiens activating transcription factor 5, mRNA (cDNA clone MGC:842 IMAGE:3504701), complete cds.
JD116530 - Sequence 97554 from Patent EP1572962.
JD179800 - Sequence 160824 from Patent EP1572962.
JD075877 - Sequence 56901 from Patent EP1572962.
JD193204 - Sequence 174228 from Patent EP1572962.
JD399442 - Sequence 380466 from Patent EP1572962.
AF305687 - Homo sapiens transcription factor ATFx mRNA, complete cds.
JD193285 - Sequence 174309 from Patent EP1572962.
JD136774 - Sequence 117798 from Patent EP1572962.
JD027014 - Sequence 8038 from Patent EP1572962.
AB463397 - Synthetic construct DNA, clone: pF1KB8134, Homo sapiens ATF5 gene for activating transcription factor 5, without stop codon, in Flexi system.
KJ905420 - Synthetic construct Homo sapiens clone ccsbBroadEn_14995 ATF5 gene, encodes complete protein.
JD019679 - Sequence 703 from Patent EP1572962.
AF101388 - Homo sapiens activating transcription factor 5 (ATF5) mRNA, partial cds.
HZ409555 - JP 2015528002-A/2152: CHIRAL CONTROL.
LG052889 - KR 1020150036642-A/2155: CHIRAL CONTROL.
JD205678 - Sequence 186702 from Patent EP1572962.
FR773048 - Homo sapiens microRNA hsa-miR-4751-5p.
HW799094 - WO 2014192907-A/200: Method for detecting miRNA used for differentiating disorders causing motor neuropathy.
HZ481926 - JP 2015535430-A/2432: TERMINALLY MODIFIED RNA.
JC514589 - Sequence 4842 from Patent WO2014113089.
LF160191 - JP 2016513950-A/257: Oligomers with improved off-target profile.
LQ072177 - Sequence 2501 from Patent EP2964234.
MA405880 - WO 2018155427-A/654: A probe with reduced false positive binding, a method to desing the probe, and the use thereof.
MA733562 - JP 2017140048-A/2432: TERMINALLY MODIFIED RNA.
JD485729 - Sequence 466753 from Patent EP1572962.
JD528652 - Sequence 509676 from Patent EP1572962.
JD514573 - Sequence 495597 from Patent EP1572962.
JD249115 - Sequence 230139 from Patent EP1572962.
JD379324 - Sequence 360348 from Patent EP1572962.
JD220209 - Sequence 201233 from Patent EP1572962.
JD229763 - Sequence 210787 from Patent EP1572962.
JD536216 - Sequence 517240 from Patent EP1572962.
JD376141 - Sequence 357165 from Patent EP1572962.
JD498038 - Sequence 479062 from Patent EP1572962.
JD276458 - Sequence 257482 from Patent EP1572962.
JD276459 - Sequence 257483 from Patent EP1572962.
JD471805 - Sequence 452829 from Patent EP1572962.
JD188824 - Sequence 169848 from Patent EP1572962.
JD361912 - Sequence 342936 from Patent EP1572962.
JD373208 - Sequence 354232 from Patent EP1572962.
JD291585 - Sequence 272609 from Patent EP1572962.
JD340429 - Sequence 321453 from Patent EP1572962.
JD486943 - Sequence 467967 from Patent EP1572962.
JD491721 - Sequence 472745 from Patent EP1572962.
JD512149 - Sequence 493173 from Patent EP1572962.
JD313431 - Sequence 294455 from Patent EP1572962.
JD401982 - Sequence 383006 from Patent EP1572962.
JD425313 - Sequence 406337 from Patent EP1572962.
JD133305 - Sequence 114329 from Patent EP1572962.
JD318332 - Sequence 299356 from Patent EP1572962.
JD309697 - Sequence 290721 from Patent EP1572962.
JD490036 - Sequence 471060 from Patent EP1572962.
JD234982 - Sequence 216006 from Patent EP1572962.
JD088947 - Sequence 69971 from Patent EP1572962.
JD373606 - Sequence 354630 from Patent EP1572962.
JD341449 - Sequence 322473 from Patent EP1572962.
JD211811 - Sequence 192835 from Patent EP1572962.
JD196725 - Sequence 177749 from Patent EP1572962.
JD436533 - Sequence 417557 from Patent EP1572962.
JD455775 - Sequence 436799 from Patent EP1572962.
JD483389 - Sequence 464413 from Patent EP1572962.
JD077439 - Sequence 58463 from Patent EP1572962.
JD218591 - Sequence 199615 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ATF5_HUMAN, ATFX, B3KND3, NM_001290746, Q9BSA1, Q9UNQ3, Q9Y2D1, uc002prd.1, uc002prd.2, uc002prd.3, uc002prd.4, uc002prd.5
UCSC ID: uc002prd.5
RefSeq Accession: NM_001193646
Protein: Q9Y2D1 (aka ATF5_HUMAN)
CCDS: CCDS12789.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.