Human Gene ATF5 (ENST00000423777.7) from GENCODE V44
Description: Homo sapiens activating transcription factor 5 (ATF5), transcript variant 3, mRNA. (from RefSeq NM_001290746)
Gencode Transcript: ENST00000423777.7
Gencode Gene: ENSG00000169136.13
Transcript (Including UTRs)
Position: hg38 chr19:49,929,205-49,933,935 Size: 4,731 Total Exon Count: 3 Strand: +
Coding Region
Position: hg38 chr19:49,930,851-49,933,092 Size: 2,242 Coding Exon Count: 2
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ATF5_HUMAN
DESCRIPTION: RecName: Full=Cyclic AMP-dependent transcription factor ATF-5; Short=cAMP-dependent transcription factor ATF-5; AltName: Full=Activating transcription factor 5; AltName: Full=Transcription factor ATFx;
FUNCTION: Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.SUBUNIT: Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34.INTERACTION: Q9NRI5:DISC1; NbExp=8; IntAct=EBI-492509, EBI-529989;SUBCELLULAR LOCATION: Cytoplasm. Nucleus.PTM: Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.SIMILARITY: Belongs to the bZIP family.SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR004827 - bZIP
Pfam Domains: PF00170 - bZIP transcription factor
ModBase Predicted Comparative 3D Structure on Q9Y2D1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK290592 - Homo sapiens cDNA FLJ77831 complete cds, highly similar to Homo sapiens mRNA for leucine-zipper protein.AK091985 - Homo sapiens cDNA FLJ34666 fis, clone LIVER2000682.AK024402 - Homo sapiens cDNA FLJ14340 fis, clone SKNMC1000091, highly similar to Cyclic AMP-dependent transcription factor ATF-5.AB021663 - Homo sapiens mRNA for leucine-zipper protein, complete cds.AB073613 - Homo sapiens primary hepatoblastoma mRNA for activating transcription factor 5, partial cds, clone:HMFN0395.JD136524 - Sequence 117548 from Patent EP1572962.JD161388 - Sequence 142412 from Patent EP1572962.JD547422 - Sequence 528446 from Patent EP1572962.BC005174 - Homo sapiens activating transcription factor 5, mRNA (cDNA clone MGC:842 IMAGE:3504701), complete cds.JD116530 - Sequence 97554 from Patent EP1572962.JD179800 - Sequence 160824 from Patent EP1572962.JD075877 - Sequence 56901 from Patent EP1572962.JD193204 - Sequence 174228 from Patent EP1572962.JD399442 - Sequence 380466 from Patent EP1572962.AF305687 - Homo sapiens transcription factor ATFx mRNA, complete cds.JD193285 - Sequence 174309 from Patent EP1572962.JD136774 - Sequence 117798 from Patent EP1572962.JD027014 - Sequence 8038 from Patent EP1572962.AB463397 - Synthetic construct DNA, clone: pF1KB8134, Homo sapiens ATF5 gene for activating transcription factor 5, without stop codon, in Flexi system.KJ905420 - Synthetic construct Homo sapiens clone ccsbBroadEn_14995 ATF5 gene, encodes complete protein.JD019679 - Sequence 703 from Patent EP1572962.AF101388 - Homo sapiens activating transcription factor 5 (ATF5) mRNA, partial cds.HZ409555 - JP 2015528002-A/2152: CHIRAL CONTROL.LG052889 - KR 1020150036642-A/2155: CHIRAL CONTROL.JD205678 - Sequence 186702 from Patent EP1572962.FR773048 - Homo sapiens microRNA hsa-miR-4751-5p.HW799094 - WO 2014192907-A/200: Method for detecting miRNA used for differentiating disorders causing motor neuropathy.HZ481926 - JP 2015535430-A/2432: TERMINALLY MODIFIED RNA.HZ791857 - JP 2016504050-A/3602: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.JC514589 - Sequence 4842 from Patent WO2014113089.LF160191 - JP 2016513950-A/257: Oligomers with improved off-target profile.LQ072177 - Sequence 2501 from Patent EP2964234.MA405880 - WO 2018155427-A/654: A probe with reduced false positive binding, a method to desing the probe, and the use thereof.MA645678 - JP 2017113010-A/3602: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.MA733562 - JP 2017140048-A/2432: TERMINALLY MODIFIED RNA.JD485729 - Sequence 466753 from Patent EP1572962.JD528652 - Sequence 509676 from Patent EP1572962.JD514573 - Sequence 495597 from Patent EP1572962.JD249115 - Sequence 230139 from Patent EP1572962.JD379324 - Sequence 360348 from Patent EP1572962.JD220209 - Sequence 201233 from Patent EP1572962.JD229763 - Sequence 210787 from Patent EP1572962.JD536216 - Sequence 517240 from Patent EP1572962.JD376141 - Sequence 357165 from Patent EP1572962.JD498038 - Sequence 479062 from Patent EP1572962.JD276458 - Sequence 257482 from Patent EP1572962.JD276459 - Sequence 257483 from Patent EP1572962.JD471805 - Sequence 452829 from Patent EP1572962.JD188824 - Sequence 169848 from Patent EP1572962.JD361912 - Sequence 342936 from Patent EP1572962.JD373208 - Sequence 354232 from Patent EP1572962.JD291585 - Sequence 272609 from Patent EP1572962.JD340429 - Sequence 321453 from Patent EP1572962.JD486943 - Sequence 467967 from Patent EP1572962.JD491721 - Sequence 472745 from Patent EP1572962.JD512149 - Sequence 493173 from Patent EP1572962.JD313431 - Sequence 294455 from Patent EP1572962.JD401982 - Sequence 383006 from Patent EP1572962.JD425313 - Sequence 406337 from Patent EP1572962.JD133305 - Sequence 114329 from Patent EP1572962.JD318332 - Sequence 299356 from Patent EP1572962.JD309697 - Sequence 290721 from Patent EP1572962.JD490036 - Sequence 471060 from Patent EP1572962.JD234982 - Sequence 216006 from Patent EP1572962.JD088947 - Sequence 69971 from Patent EP1572962.JD373606 - Sequence 354630 from Patent EP1572962.JD341449 - Sequence 322473 from Patent EP1572962.JD211811 - Sequence 192835 from Patent EP1572962.JD196725 - Sequence 177749 from Patent EP1572962.JD436533 - Sequence 417557 from Patent EP1572962.JD455775 - Sequence 436799 from Patent EP1572962.JD483389 - Sequence 464413 from Patent EP1572962.JD077439 - Sequence 58463 from Patent EP1572962.JD218591 - Sequence 199615 from Patent EP1572962.MA802731 - JP 2018183181-A/3602: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
Other Names for This Gene
Alternate Gene Symbols: ATF5_HUMAN, ATFX, B3KND3, ENST00000423777.1, ENST00000423777.2, ENST00000423777.3, ENST00000423777.4, ENST00000423777.5, ENST00000423777.6, NM_001290746, Q9BSA1, Q9UNQ3, Q9Y2D1, uc002prd.1, uc002prd.2, uc002prd.3, uc002prd.4, uc002prd.5UCSC ID: ENST00000423777.7RefSeq Accession: NM_001193646
Protein: Q9Y2D1
(aka ATF5_HUMAN)
CCDS: CCDS12789.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.