Human Gene HAS1 (ENST00000601714.5) from GENCODE V44
  Description: hyaluronan synthase 1 (from HGNC HAS1)
RefSeq Summary (NM_001523): Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gencode Transcript: ENST00000601714.5
Gencode Gene: ENSG00000105509.11
Transcript (Including UTRs)
   Position: hg38 chr19:51,713,112-51,719,941 Size: 6,830 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr19:51,713,427-51,719,928 Size: 6,502 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:51,713,112-51,719,941)mRNA (may differ from genome)Protein (585 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HAS1
Diseases sorted by gene-association score: waldenstrom macroglobulinemia (13), swine influenza (8), foodborne botulism (8), byssinosis (6), extratemporal epilepsy (6), avian influenza (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.04 RPKM in Adipose - Visceral (Omentum)
Total median expression: 53.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -114.40315-0.363 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Descriptions from all associated GenBank mRNAs
  D84424 - Homo sapiens mRNA for hyaluronan synthase, complete cds.
LF385166 - JP 2014500723-A/192669: Polycomb-Associated Non-Coding RNAs.
LQ969667 - Sequence 151 from Patent WO2014198843.
MA620743 - JP 2018138019-A/192669: Polycomb-Associated Non-Coding RNAs.
U59269 - Human hyaluronan synthase mRNA, complete cds.
BC035837 - Homo sapiens hyaluronan synthase 1, mRNA (cDNA clone MGC:46218 IMAGE:5589083), complete cds.
JD215412 - Sequence 196436 from Patent EP1572962.
JD248710 - Sequence 229734 from Patent EP1572962.
JD219477 - Sequence 200501 from Patent EP1572962.
JD216996 - Sequence 198020 from Patent EP1572962.
JD466682 - Sequence 447706 from Patent EP1572962.
JD354271 - Sequence 335295 from Patent EP1572962.
JD100593 - Sequence 81617 from Patent EP1572962.
JD396000 - Sequence 377024 from Patent EP1572962.
DQ891219 - Synthetic construct clone IMAGE:100003849; FLH170256.01X; RZPDo839D0598D hyaluronan synthase 1 (HAS1) gene, encodes complete protein.
DQ894402 - Synthetic construct Homo sapiens clone IMAGE:100008862; FLH170252.01L; RZPDo839D0597D hyaluronan synthase 1 (HAS1) gene, encodes complete protein.
AY916554 - Homo sapiens hyaluronan synthase 1 variant Va mRNA, partial cds, alternatively spliced.
AY916555 - Homo sapiens hyaluronan synthase 1 variant Vb mRNA, partial cds, aberrantly spliced.
AY916556 - Homo sapiens hyaluronan synthase 1 variant Vc mRNA, partial cds, aberrantly spliced.
LF340511 - JP 2014500723-A/148014: Polycomb-Associated Non-Coding RNAs.
MA576088 - JP 2018138019-A/148014: Polycomb-Associated Non-Coding RNAs.
AM904814 - Homo sapiens partial mRNA for hyaluronan synthase 1 (HAS1 gene).

-  Other Names for This Gene
  Alternate Gene Symbols: D84424, ENST00000601714.1, ENST00000601714.2, ENST00000601714.3, ENST00000601714.4, M0R2V0, uc002pxn.1
UCSC ID: ENST00000601714.5
RefSeq Accession: NM_001523
CCDS: CCDS12838.1, CCDS74436.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.