Human Gene ZNF765 (ENST00000396408.8) from GENCODE V44
  Description: Homo sapiens zinc finger protein 765 (ZNF765), transcript variant 1, mRNA. (from RefSeq NM_001040185)
Gencode Transcript: ENST00000396408.8
Gencode Gene: ENSG00000196417.13
Transcript (Including UTRs)
   Position: hg38 chr19:53,395,149-53,412,009 Size: 16,861 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr19:53,398,016-53,409,127 Size: 11,112 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:53,395,149-53,412,009)mRNA (may differ from genome)Protein (523 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN765_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 765;
FUNCTION: May be involved in transcriptional regulation (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.85 RPKM in Ovary
Total median expression: 56.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.40118-0.308 Picture PostScript Text
3' UTR -790.402882-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q7L2R6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK293890 - Homo sapiens cDNA FLJ50389 complete cds, moderately similar to Zinc finger protein 611.
AK316300 - Homo sapiens cDNA, FLJ79199 complete cds, highly similar to Zinc finger protein 611.
BX647981 - Homo sapiens mRNA; cDNA DKFZp686J2252 (from clone DKFZp686J2252).
AK295840 - Homo sapiens cDNA FLJ50543 complete cds.
BC140724 - Homo sapiens zinc finger protein 765, mRNA (cDNA clone MGC:176401 IMAGE:9021592), complete cds.
BC017357 - Homo sapiens zinc finger protein 765, mRNA (cDNA clone IMAGE:5094445).
BC001610 - Homo sapiens zinc finger protein 765, mRNA (cDNA clone IMAGE:3542161).
JD037074 - Sequence 18098 from Patent EP1572962.
JD468537 - Sequence 449561 from Patent EP1572962.
JD062273 - Sequence 43297 from Patent EP1572962.
EU446554 - Synthetic construct Homo sapiens clone IMAGE:100069919; IMAGE:100011763; FLH257111.01L zinc finger protein 765 (ZNF765) gene, encodes complete protein.
JD330513 - Sequence 311537 from Patent EP1572962.
JD386142 - Sequence 367166 from Patent EP1572962.
JD314888 - Sequence 295912 from Patent EP1572962.
JD330513 - Sequence 311537 from Patent EP1572962.
JD285635 - Sequence 266659 from Patent EP1572962.
JD297185 - Sequence 278209 from Patent EP1572962.
JD314888 - Sequence 295912 from Patent EP1572962.
JD314880 - Sequence 295904 from Patent EP1572962.
JD314881 - Sequence 295905 from Patent EP1572962.
JD314870 - Sequence 295894 from Patent EP1572962.
JD516174 - Sequence 497198 from Patent EP1572962.
JD516175 - Sequence 497199 from Patent EP1572962.
JD083517 - Sequence 64541 from Patent EP1572962.
JD266668 - Sequence 247692 from Patent EP1572962.
JD429123 - Sequence 410147 from Patent EP1572962.
JD285293 - Sequence 266317 from Patent EP1572962.
JD071011 - Sequence 52035 from Patent EP1572962.
JD094754 - Sequence 75778 from Patent EP1572962.
JD039903 - Sequence 20927 from Patent EP1572962.
JD300686 - Sequence 281710 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MYG0, B4DF18, B7ZAI5, B9EIL1, ENST00000396408.1, ENST00000396408.2, ENST00000396408.3, ENST00000396408.4, ENST00000396408.5, ENST00000396408.6, ENST00000396408.7, NM_001040185, Q7L2R6, Q9BV49, uc002qbm.1, uc002qbm.2, uc002qbm.3, uc002qbm.4, uc002qbm.5, ZN765_HUMAN
UCSC ID: ENST00000396408.8
RefSeq Accession: NM_001040185
Protein: Q7L2R6 (aka ZN765_HUMAN)
CCDS: CCDS46171.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.