Human Gene LENG1 (ENST00000222224.4) from GENCODE V44
  Description: Homo sapiens leukocyte receptor cluster member 1 (LENG1), mRNA. (from RefSeq NM_024316)
Gencode Transcript: ENST00000222224.4
Gencode Gene: ENSG00000105617.4
Transcript (Including UTRs)
   Position: hg38 chr19:54,155,161-54,159,721 Size: 4,561 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr19:54,155,721-54,159,695 Size: 3,975 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:54,155,161-54,159,721)mRNA (may differ from genome)Protein (264 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LENG1_HUMAN
DESCRIPTION: RecName: Full=Leukocyte receptor cluster member 1;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.
SEQUENCE CAUTION: Sequence=AAG01393.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.21 RPKM in Testis
Total median expression: 441.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.8026-0.146 Picture PostScript Text
3' UTR -261.30560-0.467 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019339 - CIR_N_dom

ModBase Predicted Comparative 3D Structure on Q96BZ8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  CU677634 - Synthetic construct Homo sapiens gateway clone IMAGE:100017482 3' read CNOT3 mRNA.
AF211966 - Homo sapiens LENG1 protein (LENG1) mRNA, partial cds.
BC014986 - Homo sapiens leukocyte receptor cluster (LRC) member 1, mRNA (cDNA clone MGC:23213 IMAGE:4877885), complete cds.
KJ894668 - Synthetic construct Homo sapiens clone ccsbBroadEn_04062 LENG1 gene, encodes complete protein.
DQ892220 - Synthetic construct clone IMAGE:100004850; FLH184204.01X; RZPDo839D04144D leukocyte receptor cluster (LRC) member 1 (LENG1) gene, encodes complete protein.
DQ895417 - Synthetic construct Homo sapiens clone IMAGE:100009877; FLH184201.01L; RZPDo839D04143D leukocyte receptor cluster (LRC) member 1 (LENG1) gene, encodes complete protein.
DQ895418 - Synthetic construct Homo sapiens clone IMAGE:100009878; FLH263670.01L; RZPDo839D05143D leukocyte receptor cluster (LRC) member 1 (LENG1) gene, encodes complete protein.
JD110241 - Sequence 91265 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000222224.1, ENST00000222224.2, ENST00000222224.3, LENG1_HUMAN, NM_024316, Q96BZ8, Q9HCU7, uc002qdm.1, uc002qdm.2, uc002qdm.3, uc002qdm.4, uc002qdm.5
UCSC ID: ENST00000222224.4
RefSeq Accession: NM_024316
Protein: Q96BZ8 (aka LENG1_HUMAN)
CCDS: CCDS12881.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.