Human Gene NCR1 (ENST00000291890.9) from GENCODE V44
  Description: Homo sapiens natural cytotoxicity triggering receptor 1 (NCR1), transcript variant 1, mRNA. (from RefSeq NM_004829)
Gencode Transcript: ENST00000291890.9
Gencode Gene: ENSG00000189430.13
Transcript (Including UTRs)
   Position: hg38 chr19:54,906,148-54,913,073 Size: 6,926 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr19:54,906,188-54,912,871 Size: 6,684 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:54,906,148-54,913,073)mRNA (may differ from genome)Protein (304 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NCR1
Diseases sorted by gene-association score: viral infectious disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.89 RPKM in Whole Blood
Total median expression: 6.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.9040-0.198 Picture PostScript Text
3' UTR -51.80202-0.256 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BC030265 - Homo sapiens cDNA clone IMAGE:5217510, **** WARNING: chimeric clone ****.
AJ001383 - Homo sapiens activating NK-receptor (NK-p46) mRNA.
JD123479 - Sequence 104503 from Patent EP1572962.
BC064806 - Homo sapiens natural cytotoxicity triggering receptor 1, mRNA (cDNA clone MGC:65100 IMAGE:5218848), complete cds.
AJ006121 - Homo sapiens mRNA for NK receptor (NKp46), isoform b.
AJ006122 - Homo sapiens mRNA for NK receptor (NKp46) isoform c.
AJ006123 - Homo sapiens mRNA for NK receptor (NKp46), isoform d.
CU687946 - Synthetic construct Homo sapiens gateway clone IMAGE:100021713 5' read NCR1 mRNA.
HQ448088 - Synthetic construct Homo sapiens clone IMAGE:100071468; CCSB011968_02 natural cytotoxicity triggering receptor 1 (NCR1) gene, encodes complete protein.
KJ892768 - Synthetic construct Homo sapiens clone ccsbBroadEn_02162 NCR1 gene, encodes complete protein.
AY346373 - Homo sapiens natural cytotoxicity triggering receptor 1 (NCR1) mRNA, complete cds; alternatively spliced.
JD154769 - Sequence 135793 from Patent EP1572962.
JD051777 - Sequence 32801 from Patent EP1572962.
JD154693 - Sequence 135717 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04650 - Natural killer cell mediated cytotoxicity

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MQZ0, ENST00000291890.1, ENST00000291890.2, ENST00000291890.3, ENST00000291890.4, ENST00000291890.5, ENST00000291890.6, ENST00000291890.7, ENST00000291890.8, NM_004829, uc002qib.1, uc002qib.2, uc002qib.3, uc002qib.4
UCSC ID: ENST00000291890.9
RefSeq Accession: NM_004829
CCDS: CCDS12911.1, CCDS46181.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.