Human Gene ZNF579 (ENST00000325421.7) from GENCODE V44
  Description: Homo sapiens zinc finger protein 579 (ZNF579), mRNA. (from RefSeq NM_152600)
Gencode Transcript: ENST00000325421.7
Gencode Gene: ENSG00000218891.5
Transcript (Including UTRs)
   Position: hg38 chr19:55,576,774-55,580,848 Size: 4,075 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr19:55,577,951-55,579,639 Size: 1,689 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:55,576,774-55,580,848)mRNA (may differ from genome)Protein (562 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 579;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 8 C2H2-type zinc fingers.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.50 RPKM in Brain - Cerebellum
Total median expression: 305.88 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.6056-0.243 Picture PostScript Text
3' UTR -393.601177-0.334 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

ModBase Predicted Comparative 3D Structure on Q8NAF0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  BC042926 - Homo sapiens, Similar to hypothetical protein FLJ35453, clone IMAGE:5243296, mRNA.
AK092772 - Homo sapiens cDNA FLJ35453 fis, clone SMINT2004414.
AX747719 - Sequence 1244 from Patent EP1308459.
JD135220 - Sequence 116244 from Patent EP1572962.
JD050435 - Sequence 31459 from Patent EP1572962.
JD191881 - Sequence 172905 from Patent EP1572962.
JD161762 - Sequence 142786 from Patent EP1572962.
JD186084 - Sequence 167108 from Patent EP1572962.
JD255246 - Sequence 236270 from Patent EP1572962.
JD458428 - Sequence 439452 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000325421.1, ENST00000325421.2, ENST00000325421.3, ENST00000325421.4, ENST00000325421.5, ENST00000325421.6, NM_152600, Q8NAF0, uc002qlh.1, uc002qlh.2, uc002qlh.3, uc002qlh.4, uc002qlh.5, ZN579_HUMAN
UCSC ID: ENST00000325421.7
RefSeq Accession: NM_152600
Protein: Q8NAF0 (aka ZN579_HUMAN)
CCDS: CCDS12927.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.