Human Gene FIZ1 (ENST00000221665.5) from GENCODE V44
Description: Homo sapiens FLT3 interacting zinc finger 1 (FIZ1), mRNA. (from RefSeq NM_032836) RefSeq Summary (NM_032836): This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000221665.5 Gencode Gene: ENSG00000179943.8 Transcript (Including UTRs) Position: hg38 chr19:55,591,376-55,599,517 Size: 8,142 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr19:55,592,450-55,597,865 Size: 5,416 Coding Exon Count: 2
ID:FIZ1_HUMAN DESCRIPTION: RecName: Full=Flt3-interacting zinc finger protein 1; AltName: Full=Zinc finger protein 798; FUNCTION: May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). SUBUNIT: Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Contains 11 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAD18728.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96SL8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0030971 receptor tyrosine kinase binding GO:0046872 metal ion binding
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter
US Server
