Description: Homo sapiens galanin-like peptide (GALP), transcript variant 1, mRNA. RefSeq Summary (NM_033106): This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]. Transcript (Including UTRs) Position: hg19 chr19:56,687,389-56,697,144 Size: 9,756 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr19:56,688,478-56,696,639 Size: 8,162 Coding Exon Count: 5
ID:GALP_HUMAN DESCRIPTION: RecName: Full=Galanin-like peptide; Flags: Precursor; FUNCTION: Hypothalamic neuropeptide which binds to the G-protein- coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin- releasing hormone secretion. Isoform 2 exhibits potent and dose- dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2 (By similarity). SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells. SIMILARITY: Belongs to the galanin family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GALP CDC HuGE Published Literature: GALP
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBC7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.