Human Gene GALP (uc002qmo.1) Description and Page Index
  Description: Homo sapiens galanin-like peptide (GALP), transcript variant 1, mRNA.
RefSeq Summary (NM_033106): This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014].
Transcript (Including UTRs)
   Position: hg19 chr19:56,687,389-56,697,144 Size: 9,756 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr19:56,688,478-56,696,639 Size: 8,162 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:56,687,389-56,697,144)mRNA (may differ from genome)Protein (116 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: GALP_HUMAN
DESCRIPTION: RecName: Full=Galanin-like peptide; Flags: Precursor;
FUNCTION: Hypothalamic neuropeptide which binds to the G-protein- coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin- releasing hormone secretion. Isoform 2 exhibits potent and dose- dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2 (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.
SIMILARITY: Belongs to the galanin family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GALP
CDC HuGE Published Literature: GALP

-  MalaCards Disease Associations
  MalaCards Gene Search: GALP
Diseases sorted by gene-association score: ganglioneuroblastoma (10), ganglioneuroma (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.11 RPKM in Testis
Total median expression: 0.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.5082-0.457 Picture PostScript Text
3' UTR -125.60505-0.249 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008174 - Galanin

Pfam Domains:
PF01296 - Galanin

ModBase Predicted Comparative 3D Structure on Q9UBC7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity

Biological Process:
GO:0007218 neuropeptide signaling pathway
GO:0008150 biological_process
GO:0009725 response to hormone
GO:0010469 regulation of receptor activity
GO:0032098 regulation of appetite
GO:0032868 response to insulin
GO:0035821 modification of morphology or physiology of other organism
GO:0042595 behavioral response to starvation
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium

Cellular Component:
GO:0005575 cellular_component
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  AF188492 - Homo sapiens clone pGR2HL14 galanin-like peptide precursor, mRNA, complete cds.
AF188493 - Homo sapiens clone pGR2HL02 galanin-like peptide precursor, mRNA, complete cds.
JD338814 - Sequence 319838 from Patent EP1572962.
JD160499 - Sequence 141523 from Patent EP1572962.
JD074568 - Sequence 55592 from Patent EP1572962.
BC141468 - Synthetic construct Homo sapiens clone IMAGE:100014766, MGC:175373 galanin-like peptide (GALP) mRNA, encodes complete protein.
BC148722 - Synthetic construct Homo sapiens clone IMAGE:100015707, MGC:183156 galanin-like peptide (GALP) mRNA, encodes complete protein.
AY329637 - Homo sapiens alarin precursor, mRNA, complete cds, alternatively spliced.
JD340009 - Sequence 321033 from Patent EP1572962.
JD146873 - Sequence 127897 from Patent EP1572962.
JD521645 - Sequence 502669 from Patent EP1572962.
JD149542 - Sequence 130566 from Patent EP1572962.
JD150477 - Sequence 131501 from Patent EP1572962.
JD538396 - Sequence 519420 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A1KXL3, GALP_HUMAN, NM_033106, NP_149097, Q9UBC7
UCSC ID: uc002qmo.1
RefSeq Accession: NM_033106
Protein: Q9UBC7 (aka GALP_HUMAN)
CCDS: CCDS12940.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033106.3
exon count: 6CDS single in 3' UTR: no RNA size: 938
ORF size: 351CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 899.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.