Human Gene ZNF582 (uc002qmy.3)
  Description: Homo sapiens zinc finger protein 582 (ZNF582), mRNA.
RefSeq Summary (NM_144690): The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
Transcript (Including UTRs)
   Position: hg19 chr19:56,894,648-56,904,894 Size: 10,247 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:56,895,232-56,904,601 Size: 9,370 Coding Exon Count: 5 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:56,894,648-56,904,894)mRNA (may differ from genome)Protein (548 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF582
Diseases sorted by gene-association score: cervical adenocarcinoma (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.26 RPKM in Testis
Total median expression: 59.20 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.80293-0.508 Picture PostScript Text
3' UTR -134.20584-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on B4DQZ9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Descriptions from all associated GenBank mRNAs
  AK055489 - Homo sapiens cDNA FLJ30927 fis, clone FEBRA2006736.
LP896146 - Sequence 1010 from Patent EP3253886.
JD314379 - Sequence 295403 from Patent EP1572962.
JD331386 - Sequence 312410 from Patent EP1572962.
JD050721 - Sequence 31745 from Patent EP1572962.
JD245568 - Sequence 226592 from Patent EP1572962.
BC101008 - Homo sapiens zinc finger protein 582, mRNA (cDNA clone MGC:119374 IMAGE:40006516), complete cds.
BC101009 - Homo sapiens zinc finger protein 582, mRNA (cDNA clone MGC:119375 IMAGE:40006517), complete cds.
BC101010 - Homo sapiens zinc finger protein 582, mRNA (cDNA clone MGC:119376 IMAGE:40006519), complete cds.
BC101011 - Homo sapiens zinc finger protein 582, mRNA (cDNA clone MGC:119377 IMAGE:40006520), complete cds.
AK299036 - Homo sapiens cDNA FLJ56135 complete cds, highly similar to Zinc finger protein 582.
AK316028 - Homo sapiens cDNA, FLJ78927 complete cds, highly similar to Zinc finger protein 582.
JD172040 - Sequence 153064 from Patent EP1572962.
EU446579 - Synthetic construct Homo sapiens clone IMAGE:100069910; IMAGE:100011788; FLH257139.01L zinc finger protein 582 (ZNF582) gene, encodes complete protein.
KJ895611 - Synthetic construct Homo sapiens clone ccsbBroadEn_05005 ZNF582 gene, encodes complete protein.
AB529213 - Synthetic construct DNA, clone: pF1KB7268, Homo sapiens ZNF582 gene for zinc finger protein 582, without stop codon, in Flexi system.
JD032199 - Sequence 13223 from Patent EP1572962.
JD314816 - Sequence 295840 from Patent EP1572962.
JD314817 - Sequence 295841 from Patent EP1572962.
JD032199 - Sequence 13223 from Patent EP1572962.
JD032199 - Sequence 13223 from Patent EP1572962.
BC011796 - Homo sapiens zinc finger protein 582, mRNA (cDNA clone IMAGE:4138993), partial cds.
BC056238 - Homo sapiens zinc finger protein 582, mRNA (cDNA clone IMAGE:6463281).
LF207504 - JP 2014500723-A/15007: Polycomb-Associated Non-Coding RNAs.
JD402263 - Sequence 383287 from Patent EP1572962.
JD252901 - Sequence 233925 from Patent EP1572962.
JD227520 - Sequence 208544 from Patent EP1572962.
JD135046 - Sequence 116070 from Patent EP1572962.
MA443081 - JP 2018138019-A/15007: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DQZ9, B4DQZ9_HUMAN, BC011796, hCG_92385, NM_144690, NP_653291
UCSC ID: uc002qmy.3
RefSeq Accession: NM_144690
Protein: B4DQZ9

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC011796.2
exon count: 5CDS single in 3' UTR: no RNA size: 752
ORF size: 1647CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3494.00frame shift in genome: no % Coverage: 97.61
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.