Human Gene ZNF667 (uc002qnd.3)
  Description: Homo sapiens zinc finger protein 667 (ZNF667), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:56,950,693-56,988,770 Size: 38,078 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:56,952,531-56,973,739 Size: 21,209 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:56,950,693-56,988,770)mRNA (may differ from genome)Protein (610 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 667;
FUNCTION: May be involved in transcriptional regulation (By similarity).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 15 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=AAH74898.2; Type=Erroneous initiation; Sequence=AAH74899.2; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF667
CDC HuGE Published Literature: ZNF667
Positive Disease Associations: Blood Pressure
Related Studies:
  1. Blood Pressure
    , , . [PubMed 0]

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.50 RPKM in Pituitary
Total median expression: 90.84 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.80189-0.433 Picture PostScript Text
3' UTR -577.891838-0.314 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
PF16622 - zinc-finger C2H2-type

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q5HYK9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  LF384213 - JP 2014500723-A/191716: Polycomb-Associated Non-Coding RNAs.
CR936605 - Homo sapiens mRNA; cDNA DKFZp686O111 (from clone DKFZp686O111).
JD023207 - Sequence 4231 from Patent EP1572962.
JD028888 - Sequence 9912 from Patent EP1572962.
BX647401 - Homo sapiens mRNA; cDNA DKFZp686M1053 (from clone DKFZp686M1053).
BC136388 - Homo sapiens zinc finger protein 667, mRNA (cDNA clone MGC:167998 IMAGE:9020375), complete cds.
BC150593 - Homo sapiens zinc finger protein 667, mRNA (cDNA clone MGC:183503 IMAGE:9056963), complete cds.
LF366742 - JP 2014500723-A/174245: Polycomb-Associated Non-Coding RNAs.
AK024073 - Homo sapiens cDNA FLJ14011 fis, clone Y79AA1002472.
AK126957 - Homo sapiens cDNA FLJ45010 fis, clone BRAWH3013009, weakly similar to Mus musculus zinc finger protein 35 (Zfp35).
AK096513 - Homo sapiens cDNA FLJ39194 fis, clone OCBBF2004930, weakly similar to ZINC FINGER PROTEIN 184.
AK056508 - Homo sapiens cDNA FLJ31946 fis, clone NT2RP7006986, highly similar to Homo sapiens zinc finger protein 667 (ZNF667), mRNA.
JD321178 - Sequence 302202 from Patent EP1572962.
JD169416 - Sequence 150440 from Patent EP1572962.
JD529269 - Sequence 510293 from Patent EP1572962.
JD430229 - Sequence 411253 from Patent EP1572962.
JD118481 - Sequence 99505 from Patent EP1572962.
JD201317 - Sequence 182341 from Patent EP1572962.
JD388419 - Sequence 369443 from Patent EP1572962.
JD523772 - Sequence 504796 from Patent EP1572962.
JD351838 - Sequence 332862 from Patent EP1572962.
JD169415 - Sequence 150439 from Patent EP1572962.
JD048120 - Sequence 29144 from Patent EP1572962.
JD238656 - Sequence 219680 from Patent EP1572962.
JD135969 - Sequence 116993 from Patent EP1572962.
JD461083 - Sequence 442107 from Patent EP1572962.
JD144731 - Sequence 125755 from Patent EP1572962.
JD425829 - Sequence 406853 from Patent EP1572962.
JD480850 - Sequence 461874 from Patent EP1572962.
JD454130 - Sequence 435154 from Patent EP1572962.
JD404889 - Sequence 385913 from Patent EP1572962.
JD498014 - Sequence 479038 from Patent EP1572962.
JD376136 - Sequence 357160 from Patent EP1572962.
JD498013 - Sequence 479037 from Patent EP1572962.
JD454129 - Sequence 435153 from Patent EP1572962.
JD454131 - Sequence 435155 from Patent EP1572962.
JD278245 - Sequence 259269 from Patent EP1572962.
BC074898 - Homo sapiens zinc finger protein 667, mRNA (cDNA clone MGC:103868 IMAGE:30915250), complete cds.
BC074899 - Homo sapiens zinc finger protein 667, mRNA (cDNA clone MGC:104035 IMAGE:30915479), complete cds.
KJ903042 - Synthetic construct Homo sapiens clone ccsbBroadEn_12436 ZNF667 gene, encodes complete protein.
JD314875 - Sequence 295899 from Patent EP1572962.
JD246153 - Sequence 227177 from Patent EP1572962.
LF366741 - JP 2014500723-A/174244: Polycomb-Associated Non-Coding RNAs.
JD202928 - Sequence 183952 from Patent EP1572962.
JD440942 - Sequence 421966 from Patent EP1572962.
JD086343 - Sequence 67367 from Patent EP1572962.
JD326450 - Sequence 307474 from Patent EP1572962.
JD428843 - Sequence 409867 from Patent EP1572962.
JD437234 - Sequence 418258 from Patent EP1572962.
MA619790 - JP 2018138019-A/191716: Polycomb-Associated Non-Coding RNAs.
MA602319 - JP 2018138019-A/174245: Polycomb-Associated Non-Coding RNAs.
MA602318 - JP 2018138019-A/174244: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5HYK9 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B2RMS6, B9EK36, NM_022103, NP_071386, Q5HYK9, Q6B093, Q9H807, ZN667_HUMAN
UCSC ID: uc002qnd.3
RefSeq Accession: NM_022103
Protein: Q5HYK9 (aka ZN667_HUMAN)
CCDS: CCDS12944.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_022103.3
exon count: 5CDS single in 3' UTR: no RNA size: 3877
ORF size: 1833CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 3809.00frame shift in genome: no % Coverage: 99.56
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.