Human Gene ZNF471 (uc002qnh.3)
  Description: Homo sapiens zinc finger protein 471 (ZNF471), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:57,019,212-57,040,269 Size: 21,058 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr19:57,022,941-57,037,317 Size: 14,377 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:57,019,212-57,040,269)mRNA (may differ from genome)Protein (626 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 471; AltName: Full=EZFIT-related protein 1;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 15 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=AAC32422.1; Type=Erroneous gene model prediction;

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.50 RPKM in Ovary
Total median expression: 180.30 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.80133-0.329 Picture PostScript Text
3' UTR -943.322952-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9BX82
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AL831845 - Homo sapiens mRNA; cDNA DKFZp451H135 (from clone DKFZp451H135).
LF384214 - JP 2014500723-A/191717: Polycomb-Associated Non-Coding RNAs.
AK293908 - Homo sapiens cDNA FLJ59573 complete cds, moderately similar to Zinc finger protein 471.
AK291416 - Homo sapiens cDNA FLJ76852 complete cds, highly similar to Homo sapiens zinc finger protein 471 (ZNF471), mRNA.
AF352026 - Homo sapiens EZFIT-related protein 1 mRNA, complete cds.
BC125222 - Homo sapiens zinc finger protein 471, mRNA (cDNA clone MGC:150658 IMAGE:40124080), complete cds.
BC125221 - Homo sapiens zinc finger protein 471, mRNA (cDNA clone MGC:150657 IMAGE:40124078), complete cds.
JD403114 - Sequence 384138 from Patent EP1572962.
JD380486 - Sequence 361510 from Patent EP1572962.
JD429908 - Sequence 410932 from Patent EP1572962.
AM393402 - Synthetic construct Homo sapiens clone IMAGE:100002368 for hypothetical protein (ZNF471 gene).
AB037817 - Homo sapiens mRNA for KIAA1396 protein, partial cds.
JD314875 - Sequence 295899 from Patent EP1572962.
JD314870 - Sequence 295894 from Patent EP1572962.
JD314870 - Sequence 295894 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
JD037114 - Sequence 18138 from Patent EP1572962.
DQ595179 - Homo sapiens piRNA piR-61291, complete sequence.
JD371655 - Sequence 352679 from Patent EP1572962.
JD518234 - Sequence 499258 from Patent EP1572962.
JD401276 - Sequence 382300 from Patent EP1572962.
JD034205 - Sequence 15229 from Patent EP1572962.
JD141752 - Sequence 122776 from Patent EP1572962.
JD154980 - Sequence 136004 from Patent EP1572962.
JD206153 - Sequence 187177 from Patent EP1572962.
JD209749 - Sequence 190773 from Patent EP1572962.
JD474271 - Sequence 455295 from Patent EP1572962.
JD102479 - Sequence 83503 from Patent EP1572962.
JD498930 - Sequence 479954 from Patent EP1572962.
JD308843 - Sequence 289867 from Patent EP1572962.
JD432073 - Sequence 413097 from Patent EP1572962.
JD098358 - Sequence 79382 from Patent EP1572962.
JD337798 - Sequence 318822 from Patent EP1572962.
JD067070 - Sequence 48094 from Patent EP1572962.
JD152893 - Sequence 133917 from Patent EP1572962.
JD368140 - Sequence 349164 from Patent EP1572962.
JD442258 - Sequence 423282 from Patent EP1572962.
JD109592 - Sequence 90616 from Patent EP1572962.
JD173616 - Sequence 154640 from Patent EP1572962.
JD442369 - Sequence 423393 from Patent EP1572962.
JD279183 - Sequence 260207 from Patent EP1572962.
JD468085 - Sequence 449109 from Patent EP1572962.
JD369335 - Sequence 350359 from Patent EP1572962.
JD494028 - Sequence 475052 from Patent EP1572962.
JD171348 - Sequence 152372 from Patent EP1572962.
BC028227 - Homo sapiens zinc finger protein 471, mRNA (cDNA clone IMAGE:5241098).
KJ906279 - Synthetic construct Homo sapiens clone ccsbBroadEn_15949 ZNF471 gene, encodes complete protein.
JD063305 - Sequence 44329 from Patent EP1572962.
BC016830 - Homo sapiens zinc finger protein 471, mRNA (cDNA clone IMAGE:4337808).
JD063287 - Sequence 44311 from Patent EP1572962.
JD444344 - Sequence 425368 from Patent EP1572962.
JD181383 - Sequence 162407 from Patent EP1572962.
JD371710 - Sequence 352734 from Patent EP1572962.
JD510272 - Sequence 491296 from Patent EP1572962.
JD546916 - Sequence 527940 from Patent EP1572962.
JD548568 - Sequence 529592 from Patent EP1572962.
JD528841 - Sequence 509865 from Patent EP1572962.
JD284382 - Sequence 265406 from Patent EP1572962.
JD284278 - Sequence 265302 from Patent EP1572962.
JD503169 - Sequence 484193 from Patent EP1572962.
JD373803 - Sequence 354827 from Patent EP1572962.
JD220663 - Sequence 201687 from Patent EP1572962.
JD245797 - Sequence 226821 from Patent EP1572962.
JD308322 - Sequence 289346 from Patent EP1572962.
JD256200 - Sequence 237224 from Patent EP1572962.
JD162500 - Sequence 143524 from Patent EP1572962.
JD197690 - Sequence 178714 from Patent EP1572962.
JD212261 - Sequence 193285 from Patent EP1572962.
JD412503 - Sequence 393527 from Patent EP1572962.
JD512070 - Sequence 493094 from Patent EP1572962.
JD250443 - Sequence 231467 from Patent EP1572962.
JD358308 - Sequence 339332 from Patent EP1572962.
JD166202 - Sequence 147226 from Patent EP1572962.
JD562254 - Sequence 543278 from Patent EP1572962.
MA619791 - JP 2018138019-A/191717: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BX82 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ERP1, KIAA1396, NM_020813, NP_065864, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1, ZN471_HUMAN
UCSC ID: uc002qnh.3
RefSeq Accession: NM_020813
Protein: Q9BX82 (aka ZN471_HUMAN or Z471_HUMAN)
CCDS: CCDS12945.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_020813.2
exon count: 5CDS single in 3' UTR: no RNA size: 4967
ORF size: 1881CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3837.00frame shift in genome: no % Coverage: 99.98
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.