Human Gene ZFP28 (uc002qni.3) Description and Page Index
  Description: Homo sapiens ZFP28 zinc finger protein (ZFP28), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:57,050,317-57,064,504 Size: 14,188 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr19:57,050,388-57,062,126 Size: 11,739 Coding Exon Count: 7 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:57,050,317-57,064,504)mRNA (may differ from genome)Protein (349 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: ZFP28
Diseases sorted by gene-association score: alternating hemiplegia of childhood (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.14 RPKM in Testis
Total median expression: 118.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -24.0071-0.338 Picture PostScript Text
3' UTR -550.712378-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box

Pfam Domains:
PF01352 - KRAB box

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)

ModBase Predicted Comparative 3D Structure on A8K0L8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  JD408560 - Sequence 389584 from Patent EP1572962.
AB037852 - Homo sapiens KIAA1431 mRNA for KIAA1431 protein.
AF507045 - Homo sapiens zinc finger protein 28 (ZFP28) mRNA, complete cds.
BC028416 - Homo sapiens zinc finger protein 28 homolog (mouse), mRNA (cDNA clone IMAGE:4823721), complete cds.
BC099903 - Homo sapiens zinc finger protein 28 homolog (mouse), mRNA (cDNA clone IMAGE:5261371), complete cds.
AK289583 - Homo sapiens cDNA FLJ76998 complete cds, highly similar to Homo sapiens zinc finger protein 28 homolog (mouse), mRNA.
BC127002 - Homo sapiens zinc finger protein 28 homolog (mouse), mRNA (cDNA clone MGC:149136 IMAGE:40108311), complete cds.
BC127003 - Homo sapiens zinc finger protein 28 homolog (mouse), mRNA (cDNA clone MGC:149137 IMAGE:40108312), complete cds.
KJ906427 - Synthetic construct Homo sapiens clone ccsbBroadEn_16097 ZFP28 gene, encodes complete protein.
KJ900196 - Synthetic construct Homo sapiens clone ccsbBroadEn_09590 ZFP28 gene, encodes complete protein.
CU688496 - Synthetic construct Homo sapiens gateway clone IMAGE:100018164 5' read ZFP28 mRNA.
AB384204 - Synthetic construct DNA, clone: pF1KSDA1431, Homo sapiens ZFP28 gene for zinc finger protein 28 homolog, complete cds, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K0L8, A8K0L8_HUMAN, AK289583, NM_020828, NP_065879
UCSC ID: uc002qni.3
RefSeq Accession: NM_020828
Protein: A8K0L8

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK289583.1
exon count: 7CDS single in 3' UTR: no RNA size: 1219
ORF size: 1050CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 2168.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 2530# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.