Human Gene TRIM54 (ENST00000296098.4) Description and Page Index
Description: Homo sapiens tripartite motif containing 54 (TRIM54), transcript variant 1, mRNA. (from RefSeq NM_032546) RefSeq Summary (NM_032546): The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000296098.4 Gencode Gene: ENSG00000138100.13 Transcript (Including UTRs) Position: hg38 chr2:27,282,462-27,307,439 Size: 24,978 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr2:27,282,732-27,306,541 Size: 23,810 Coding Exon Count: 9
ID:TRI54_HUMAN DESCRIPTION: RecName: Full=Tripartite motif-containing protein 54; AltName: Full=Muscle-specific RING finger protein; Short=MuRF; AltName: Full=Muscle-specific RING finger protein 3; Short=MuRF-3; Short=MuRF3; AltName: Full=RING finger protein 30; FUNCTION: May bind and stabilize microtubules during myotubes formation (By similarity). SUBUNIT: Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and probably with TRIM55. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). TISSUE SPECIFICITY: Specifically expressed in heart and skeletal muscle. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 COS domain. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=AAY24296.1; Type=Erroneous initiation; Sequence=CAC32841.1; Type=Erroneous initiation; Sequence=CAC32842.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYV2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK300699 - Homo sapiens cDNA FLJ60896 complete cds, highly similar to Tripartite motif-containing protein 54. AK311516 - Homo sapiens cDNA, FLJ18558. BC141807 - Homo sapiens tripartite motif-containing 54, mRNA (cDNA clone MGC:164792 IMAGE:40147443), complete cds. AJ291714 - Homo sapiens mRNA for RNF30 gene for ring finger protein 30.