Human Gene TRIM54 (ENST00000296098.4) Description and Page Index
  Description: Homo sapiens tripartite motif containing 54 (TRIM54), transcript variant 1, mRNA. (from RefSeq NM_032546)
RefSeq Summary (NM_032546): The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000296098.4
Gencode Gene: ENSG00000138100.13
Transcript (Including UTRs)
   Position: hg38 chr2:27,282,462-27,307,439 Size: 24,978 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr2:27,282,732-27,306,541 Size: 23,810 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:27,282,462-27,307,439)mRNA (may differ from genome)Protein (400 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 54; AltName: Full=Muscle-specific RING finger protein; Short=MuRF; AltName: Full=Muscle-specific RING finger protein 3; Short=MuRF-3; Short=MuRF3; AltName: Full=RING finger protein 30;
FUNCTION: May bind and stabilize microtubules during myotubes formation (By similarity).
SUBUNIT: Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and probably with TRIM55.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity).
TISSUE SPECIFICITY: Specifically expressed in heart and skeletal muscle.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 COS domain.
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=AAY24296.1; Type=Erroneous initiation; Sequence=CAC32841.1; Type=Erroneous initiation; Sequence=CAC32842.1; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: TRIM54
Diseases sorted by gene-association score: cardiac rupture (7), cardiomyopathy, familial hypertrophic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 219.32 RPKM in Muscle - Skeletal
Total median expression: 430.89 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -66.20270-0.245 Picture PostScript Text
3' UTR -234.60554-0.423 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017903 - COS_domain
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00643 - B-box zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9BYV2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0007017 microtubule-based process
GO:0007026 negative regulation of microtubule depolymerization
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
GO:0055001 muscle cell development
GO:0070507 regulation of microtubule cytoskeleton organization

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030018 Z disc

-  Descriptions from all associated GenBank mRNAs
  AK300699 - Homo sapiens cDNA FLJ60896 complete cds, highly similar to Tripartite motif-containing protein 54.
AK311516 - Homo sapiens cDNA, FLJ18558.
BC141807 - Homo sapiens tripartite motif-containing 54, mRNA (cDNA clone MGC:164792 IMAGE:40147443), complete cds.
AJ291714 - Homo sapiens mRNA for RNF30 gene for ring finger protein 30.

-  Other Names for This Gene
  Alternate Gene Symbols: A5D8T7, MURF, MURF3, NM_032546, Q53SY4, Q9BYV2, Q9BYV3, RNF30, TRI54_HUMAN, uc002rjn.1, uc002rjn.2, uc002rjn.3, uc002rjn.4
UCSC ID: uc002rjn.4
RefSeq Accession: NM_032546
Protein: Q9BYV2 (aka TRI54_HUMAN)
CCDS: CCDS1745.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.