Human Gene FEZ2 (ENST00000413938.5) from GENCODE V44
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt F8WB37)
RefSeq Summary (NM_005102): This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000413938.5
Gencode Gene: ENSG00000171055.15
Transcript (Including UTRs)
   Position: hg38 chr2:36,552,258-36,594,566 Size: 42,309 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr2:36,581,588-36,590,974 Size: 9,387 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:36,552,258-36,594,566)mRNA (may differ from genome)Protein (63 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: F8WB37_HUMAN
DESCRIPTION: SubName: Full=Fasciculation and elongation protein zeta-2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.43 RPKM in Muscle - Skeletal
Total median expression: 551.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.10190-0.232 Picture PostScript Text
3' UTR -372.801558-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011680 - FEZ

Pfam Domains:
PF07763 - FEZ-like protein

ModBase Predicted Comparative 3D Structure on F8WB37
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BC110386 - Homo sapiens fasciculation and elongation protein zeta 2 (zygin II), mRNA (cDNA clone MGC:117372 IMAGE:5183735), complete cds.
U60061 - Human FEZ2 mRNA, partial cds.
AK025274 - Homo sapiens cDNA: FLJ21621 fis, clone COL07851, highly similar to HSU60061 Human FEZ2 mRNA.
BX537785 - Homo sapiens mRNA; cDNA DKFZp779C2259 (from clone DKFZp779C2259); complete cds.
AF113124 - Homo sapiens FEZ2 protein (FEZ2) mRNA, complete cds.
BC089390 - Homo sapiens fasciculation and elongation protein zeta 2 (zygin II), mRNA (cDNA clone IMAGE:30390539), partial cds.
BC047020 - Homo sapiens cDNA clone IMAGE:5228798.
BC037566 - Homo sapiens fasciculation and elongation protein zeta 2 (zygin II), mRNA (cDNA clone IMAGE:5217090).
AB209719 - Homo sapiens mRNA for fasciculation and elongation protein zeta 2 variant protein.
AB076184 - Homo sapiens FEZ2 mRNA for fasciculation and elongation protein zeta 2, complete cds.
U69140 - Human zyginII mRNA, partial cds.
AK057492 - Homo sapiens cDNA FLJ32930 fis, clone TESTI2007422.
AL117593 - Homo sapiens mRNA; cDNA DKFZp564G082 (from clone DKFZp564G082).
JD102193 - Sequence 83217 from Patent EP1572962.
JD260431 - Sequence 241455 from Patent EP1572962.
JD113256 - Sequence 94280 from Patent EP1572962.
JD119987 - Sequence 101011 from Patent EP1572962.
JD538540 - Sequence 519564 from Patent EP1572962.
JD503225 - Sequence 484249 from Patent EP1572962.
JD261895 - Sequence 242919 from Patent EP1572962.
JD239907 - Sequence 220931 from Patent EP1572962.
LF210925 - JP 2014500723-A/18428: Polycomb-Associated Non-Coding RNAs.
MA446502 - JP 2018138019-A/18428: Polycomb-Associated Non-Coding RNAs.
BC064484 - Homo sapiens fasciculation and elongation protein zeta 2 (zygin II), mRNA (cDNA clone IMAGE:5476588), partial cds.
BC018032 - Homo sapiens fasciculation and elongation protein zeta 2 (zygin II), mRNA (cDNA clone IMAGE:4801164), partial cds.
BC054043 - Homo sapiens fasciculation and elongation protein zeta 2 (zygin II), mRNA (cDNA clone IMAGE:6008102), partial cds.
LF342132 - JP 2014500723-A/149635: Polycomb-Associated Non-Coding RNAs.
MA577709 - JP 2018138019-A/149635: Polycomb-Associated Non-Coding RNAs.
L17328 - Human pre-T/NK cell associated protein (3Cl) mRNA, complete cds.
JD166827 - Sequence 147851 from Patent EP1572962.
JD397540 - Sequence 378564 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BX537785, ENST00000413938.1, ENST00000413938.2, ENST00000413938.3, ENST00000413938.4, F8WB37, F8WB37_HUMAN, uc002rpf.1, uc002rpf.2, uc002rpf.3
UCSC ID: ENST00000413938.5
RefSeq Accession: NM_005102
Protein: F8WB37

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.