Human Gene ATL2 (ENST00000419554.6) from GENCODE V44
Description: Homo sapiens atlastin GTPase 2 (ATL2), transcript variant 1, mRNA. (from RefSeq NM_022374)
Gencode Transcript: ENST00000419554.6
Gencode Gene: ENSG00000119787.14
Transcript (Including UTRs)
Position: hg38 chr2:38,295,901-38,377,273 Size: 81,373 Total Exon Count: 13 Strand: -
Coding Region
Position: hg38 chr2:38,296,483-38,377,260 Size: 80,778 Coding Exon Count: 13
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ATLA2_HUMAN
DESCRIPTION: RecName: Full=Atlastin-2; EC=3.6.5.-; AltName: Full=ADP-ribosylation factor-like protein 6-interacting protein 2; Short=ARL-6-interacting protein 2; Short=Aip-2;
FUNCTION: GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.SUBUNIT: Interacts with REEP5 and RTN3.INTERACTION: Q60870:Reep5 (xeno); NbExp=2; IntAct=EBI-2410430, EBI-2410304; Q9ES97-3:Rtn3 (xeno); NbExp=2; IntAct=EBI-2410430, EBI-1487798;SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in peripheral tissues (at protein level).SIMILARITY: Belongs to the GBP family. Atlastin subfamily.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR003191 - Guanylate-bd_C
IPR015894 - Guanylate-bd_N
Pfam Domains: PF02263 - Guanylate-binding protein, N-terminal domain
PF02841 - Guanylate-binding protein, C-terminal domain
ModBase Predicted Comparative 3D Structure on Q8NHH9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC039050 - Homo sapiens ADP-ribosylation factor-like 6 interacting protein 2, mRNA (cDNA clone IMAGE:3450768), partial cds.AK124434 - Homo sapiens cDNA FLJ42443 fis, clone BLADE2008461.AK225190 - Homo sapiens mRNA for ARL6IP2 variant, clone: COL01262.AK316179 - Homo sapiens cDNA, FLJ79078 complete cds, highly similar to Mus musculus ADP-ribosylation factor-like 6 interacting protein 2.AK302621 - Homo sapiens cDNA FLJ51152 complete cds, highly similar to Homo sapiens ADP-ribosylation factor-like 6 interacting protein 2 (ARL6IP2), mRNA.AK303985 - Homo sapiens cDNA FLJ51186 complete cds, highly similar to Homo sapiens ADP-ribosylation factor-like 6 interacting protein 2 (ARL6IP2), mRNA.AK294049 - Homo sapiens cDNA FLJ53876 complete cds, highly similar to Homo sapiens ADP-ribosylation factor-like 6 interacting protein 2 (ARL6IP2), mRNA.BC053508 - Homo sapiens atlastin GTPase 2, mRNA (cDNA clone MGC:59735 IMAGE:6338889), complete cds.AK026946 - Homo sapiens cDNA: FLJ23293 fis, clone HEP10514.KJ903069 - Synthetic construct Homo sapiens clone ccsbBroadEn_12463 ATL2 gene, encodes complete protein.AK294711 - Homo sapiens cDNA FLJ57300 complete cds, highly similar to Homo sapiens ADP-ribosylation factor-like 6 interacting protein 2 (ARL6IP2), mRNA.JD511230 - Sequence 492254 from Patent EP1572962.JD486765 - Sequence 467789 from Patent EP1572962.JD353420 - Sequence 334444 from Patent EP1572962.AK308894 - Homo sapiens cDNA, FLJ98935.CU690972 - Synthetic construct Homo sapiens gateway clone IMAGE:100022512 5' read ARL6IP2 mRNA.
Other Names for This Gene
Alternate Gene Symbols: ARL6IP2, ATLA2_HUMAN, B7Z1X2, ENST00000419554.1, ENST00000419554.2, ENST00000419554.3, ENST00000419554.4, ENST00000419554.5, NM_022374, Q4ZG30, Q7Z630, Q8NHH8, Q8NHH9, Q9H5M7, uc002rqs.1, uc002rqs.2, uc002rqs.3, uc002rqs.4UCSC ID: ENST00000419554.6RefSeq Accession: NM_022374
Protein: Q8NHH9
(aka ATLA2_HUMAN)
CCDS: CCDS1795.1
Methods, Credits, and Use Restrictions
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