ID:COMD1_HUMAN DESCRIPTION: RecName: Full=COMM domain-containing protein 1; AltName: Full=Protein Murr1; FUNCTION: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. SUBUNIT: Monomer and homodimer. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8 and COMMD10 (via COMM domain). Identified in a complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin C, CUL2, SOCS1 and RBX1. Interacts directly with SOCS1 and CUL2. Interacts directly the N- terminal region of ATP7B. Interacts with CCS, CDKN2A, RELA and NFKBIB. Identified in a complex with NF-kappa-B. Interacts with CLU. INTERACTION: Self; NbExp=2; IntAct=EBI-1550112, EBI-1550112; Q9UBI1:COMMD3; NbExp=3; IntAct=EBI-1550112, EBI-714979; Q9H0A8:COMMD4; NbExp=2; IntAct=EBI-1550112, EBI-1550064; Q7Z4G1:COMMD6; NbExp=2; IntAct=EBI-1550112, EBI-1550081; P25963:NFKBIA; NbExp=3; IntAct=EBI-1550112, EBI-307386; Q04864:REL; NbExp=3; IntAct=EBI-1550112, EBI-307352; Q04206:RELA; NbExp=7; IntAct=EBI-1550112, EBI-73886; Q01201:RELB; NbExp=2; IntAct=EBI-1550112, EBI-357837; P51172:SCNN1D; NbExp=3; IntAct=EBI-1550112, EBI-2547114; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. TISSUE SPECIFICITY: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. PTM: Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation. SIMILARITY: Contains 1 COMM domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N668
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005507 copper ion binding GO:0005515 protein binding GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding GO:0008289 lipid binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0043325 phosphatidylinositol-3,4-bisphosphate binding GO:0046872 metal ion binding GO:0070300 phosphatidic acid binding GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006893 Golgi to plasma membrane transport GO:0015031 protein transport GO:0031398 positive regulation of protein ubiquitination GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043687 post-translational protein modification GO:0048227 plasma membrane to endosome transport GO:0055070 copper ion homeostasis GO:1902306 negative regulation of sodium ion transmembrane transport GO:2000009 negative regulation of protein localization to cell surface
US Server
