Human Gene UGP2 (ENST00000394417.7) from GENCODE V44
Description: Homo sapiens UDP-glucose pyrophosphorylase 2 (UGP2), transcript variant 7, mRNA. (from RefSeq NM_001377528) RefSeq Summary (NM_001001521): The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000394417.7 Gencode Gene: ENSG00000169764.16 Transcript (Including UTRs) Position: hg38 chr2:63,840,969-63,891,560 Size: 50,592 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr2:63,856,320-63,891,227 Size: 34,908 Coding Exon Count: 9
ID:UGPA_HUMAN DESCRIPTION: RecName: Full=UTP--glucose-1-phosphate uridylyltransferase; EC=2.7.7.9; AltName: Full=UDP-glucose pyrophosphorylase; Short=UDPGP; Short=UGPase; FUNCTION: Plays a central role as a glucosyl donor in cellular metabolic pathways. CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. SUBUNIT: Homooctamer (By similarity). INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-743729, EBI-401755; SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the UDPGP type 1 family. CAUTION: The human genome was initially thought to contain 2 genes for UTP--glucose-1-phosphate uridylyltransferase: UGP1 and UGP2. However, the sequence defined as UGP1 (PubMed:8354390) probably does not exist and corresponds to UGP2.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16851
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity GO:0005515 protein binding GO:0005536 glucose binding GO:0016740 transferase activity GO:0016779 nucleotidyltransferase activity GO:0032557 pyrimidine ribonucleotide binding GO:0042802 identical protein binding GO:0046872 metal ion binding GO:0070569 uridylyltransferase activity
Biological Process: GO:0005977 glycogen metabolic process GO:0005978 glycogen biosynthetic process GO:0006011 UDP-glucose metabolic process GO:0006065 UDP-glucuronate biosynthetic process GO:0008152 metabolic process GO:0019255 glucose 1-phosphate metabolic process
US Server
