Human Gene FAM136A (ENST00000037869.8) from GENCODE V44
Description: Homo sapiens family with sequence similarity 136 member A (FAM136A), transcript variant 1, mRNA. (from RefSeq NM_032822) RefSeq Summary (NM_032822): This gene encodes a mitochondrially localized protein that is highly conserved across species. The gene is expressed in a variety of tissues including human lymphoblast cells and rat neurosensorial epithelium of the cristaampullaris. A mutation in this gene has been associated with familial Meniere's disease, a chronic disorder of the inner ear. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. Gencode Transcript: ENST00000037869.8 Gencode Gene: ENSG00000035141.9 Transcript (Including UTRs) Position: hg38 chr2:70,295,976-70,302,067 Size: 6,092 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr2:70,297,289-70,302,011 Size: 4,723 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05811 - Eukaryotic protein of unknown function (DUF842)
ModBase Predicted Comparative 3D Structure on Q96C01
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
