Human Gene TRIM43 (ENST00000272395.3) from GENCODE V44
  Description: Homo sapiens tripartite motif containing 43 (TRIM43), mRNA. (from RefSeq NM_138800)
Gencode Transcript: ENST00000272395.3
Gencode Gene: ENSG00000144015.5
Transcript (Including UTRs)
   Position: hg38 chr2:95,592,001-95,599,778 Size: 7,778 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr2:95,594,024-95,599,573 Size: 5,550 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:95,592,001-95,599,778)mRNA (may differ from genome)Protein (446 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TRI43_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 43;
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TRIM43
Diseases sorted by gene-association score: facioscapulohumeral muscular dystrophy 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.14 RPKM in Testis
Total median expression: 0.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.70153-0.292 Picture PostScript Text
3' UTR -32.60205-0.159 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00622 - SPRY domain

ModBase Predicted Comparative 3D Structure on Q96BQ3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  BC015353 - Homo sapiens tripartite motif-containing 43, mRNA (cDNA clone MGC:21446 IMAGE:3445177), complete cds.
JD204243 - Sequence 185267 from Patent EP1572962.
EU447016 - Synthetic construct Homo sapiens clone IMAGE:100070098; IMAGE:100012225; FLH257484.01L tripartite motif-containing 43 (TRIM43) gene, encodes complete protein.
KJ895463 - Synthetic construct Homo sapiens clone ccsbBroadEn_04857 TRIM43 gene, encodes complete protein.
JD563070 - Sequence 544094 from Patent EP1572962.
JD110604 - Sequence 91628 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000272395.1, ENST00000272395.2, NM_138800, Q53TJ7, Q96BQ3, TRI43_HUMAN, uc002suv.1, uc002suv.2, uc002suv.3, uc002suv.4, uc002suv.5
UCSC ID: ENST00000272395.3
RefSeq Accession: NM_138800
Protein: Q96BQ3 (aka TRI43_HUMAN)
CCDS: CCDS2015.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.