Human Gene ZC3H6 (ENST00000409871.6) from GENCODE V44
  Description: Homo sapiens zinc finger CCCH-type containing 6 (ZC3H6), mRNA. (from RefSeq NM_198581)
Gencode Transcript: ENST00000409871.6
Gencode Gene: ENSG00000188177.15
Transcript (Including UTRs)
   Position: hg38 chr2:112,275,597-112,340,059 Size: 64,463 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg38 chr2:112,275,995-112,332,488 Size: 56,494 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:112,275,597-112,340,059)mRNA (may differ from genome)Protein (1189 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZC3H6_HUMAN
DESCRIPTION: RecName: Full=Zinc finger CCCH domain-containing protein 6;
SIMILARITY: Contains 3 C3H1-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAC85608.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC87128.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC87128.1; Type=Frameshift; Positions=1120;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.60 RPKM in Nerve - Tibial
Total median expression: 117.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -172.80398-0.434 Picture PostScript Text
3' UTR -1977.907571-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000571 - Znf_CCCH

Pfam Domains:
PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)

ModBase Predicted Comparative 3D Structure on P61129
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0046872 metal ion binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  AK131416 - Homo sapiens cDNA FLJ16526 fis, clone OCBBF2006987.
AB111887 - Homo sapiens mRNA for KIAA2035 protein.
BC155540 - Homo sapiens zinc finger CCCH-type containing 6, mRNA (cDNA clone IMAGE:8860501), partial cds.
BC167154 - Homo sapiens zinc finger CCCH-type containing 6, mRNA (cDNA clone IMAGE:8862557), partial cds.
AK127776 - Homo sapiens cDNA FLJ45877 fis, clone OCBBF3008835.
AK123404 - Homo sapiens cDNA FLJ41410 fis, clone BRHIP2001074.
BX649154 - Homo sapiens mRNA; cDNA DKFZp686J15116 (from clone DKFZp686J15116).
JD506954 - Sequence 487978 from Patent EP1572962.
JD046198 - Sequence 27222 from Patent EP1572962.
JD273776 - Sequence 254800 from Patent EP1572962.
DQ591659 - Homo sapiens piRNA piR-58771, complete sequence.
AL831901 - Homo sapiens mRNA; cDNA DKFZp547C239 (from clone DKFZp547C239).
JD153654 - Sequence 134678 from Patent EP1572962.
JD428381 - Sequence 409405 from Patent EP1572962.
JD293420 - Sequence 274444 from Patent EP1572962.
JD435408 - Sequence 416432 from Patent EP1572962.
JD174216 - Sequence 155240 from Patent EP1572962.
JD356411 - Sequence 337435 from Patent EP1572962.
JD505882 - Sequence 486906 from Patent EP1572962.
JD094125 - Sequence 75149 from Patent EP1572962.
JD094126 - Sequence 75150 from Patent EP1572962.
JD120570 - Sequence 101594 from Patent EP1572962.
JD379683 - Sequence 360707 from Patent EP1572962.
JD379684 - Sequence 360708 from Patent EP1572962.
JD120571 - Sequence 101595 from Patent EP1572962.
JD094124 - Sequence 75148 from Patent EP1572962.
JD311806 - Sequence 292830 from Patent EP1572962.
JD311807 - Sequence 292831 from Patent EP1572962.
JD081608 - Sequence 62632 from Patent EP1572962.
JD371201 - Sequence 352225 from Patent EP1572962.
JD197876 - Sequence 178900 from Patent EP1572962.
JD212502 - Sequence 193526 from Patent EP1572962.
JD397766 - Sequence 378790 from Patent EP1572962.
JD071697 - Sequence 52721 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A9JR71, ENST00000409871.1, ENST00000409871.2, ENST00000409871.3, ENST00000409871.4, ENST00000409871.5, KIAA2035, NM_198581, P61129, Q6ZW96, uc002thq.1, uc002thq.2, uc002thq.3, ZC3H6_HUMAN, ZC3HDC6
UCSC ID: ENST00000409871.6
RefSeq Accession: NM_198581
Protein: P61129 (aka ZC3H6_HUMAN)
CCDS: CCDS46393.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.