Human Gene TTL (ENST00000233336.7) from GENCODE V44
Description: Homo sapiens tubulin tyrosine ligase (TTL), transcript variant 1, mRNA. (from RefSeq NM_153712) RefSeq Summary (NM_153712): TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000233336.7 Gencode Gene: ENSG00000114999.8 Transcript (Including UTRs) Position: hg38 chr2:112,482,156-112,541,739 Size: 59,584 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr2:112,482,345-112,528,795 Size: 46,451 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03133 - Tubulin-tyrosine ligase family
ModBase Predicted Comparative 3D Structure on Q8NG68
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC036819 - Homo sapiens tubulin tyrosine ligase, mRNA (cDNA clone MGC:46235 IMAGE:5767758), complete cds. JD473760 - Sequence 454784 from Patent EP1572962. JD459078 - Sequence 440102 from Patent EP1572962. AB071393 - Homo sapiens TTL mRNA for tubulin tyrosine ligase, complete cds. CU691434 - Synthetic construct Homo sapiens gateway clone IMAGE:100019143 5' read TTL mRNA. KJ900274 - Synthetic construct Homo sapiens clone ccsbBroadEn_09668 TTL gene, encodes complete protein. DQ894075 - Synthetic construct Homo sapiens clone IMAGE:100008535; FLH167441.01L; RZPDo839A0789D tubulin tyrosine ligase (TTL) gene, encodes complete protein. AK126549 - Homo sapiens cDNA FLJ44585 fis, clone ASTRO2008972, highly similar to Tubulin--tyrosine ligase (EC 6.3.2.25). BX647135 - Homo sapiens mRNA; cDNA DKFZp686A03171 (from clone DKFZp686A03171). BX538316 - Homo sapiens mRNA; cDNA DKFZp686I16132 (from clone DKFZp686I16132). BC036331 - Homo sapiens tubulin tyrosine ligase, mRNA (cDNA clone IMAGE:3865811), with apparent retained intron. BC036707 - Homo sapiens tubulin tyrosine ligase, mRNA (cDNA clone IMAGE:4560661), partial cds. AK126378 - Homo sapiens cDNA FLJ44414 fis, clone UTERU1000339. BX649144 - Homo sapiens mRNA; cDNA DKFZp686C2044 (from clone DKFZp686C2044). JD354965 - Sequence 335989 from Patent EP1572962. JD121596 - Sequence 102620 from Patent EP1572962. JD535396 - Sequence 516420 from Patent EP1572962. JD130926 - Sequence 111950 from Patent EP1572962. JD156776 - Sequence 137800 from Patent EP1572962. JD189092 - Sequence 170116 from Patent EP1572962. JD280222 - Sequence 261246 from Patent EP1572962. JD224120 - Sequence 205144 from Patent EP1572962. JD515703 - Sequence 496727 from Patent EP1572962. JD511192 - Sequence 492216 from Patent EP1572962. AK026673 - Homo sapiens cDNA: FLJ23020 fis, clone LNG00943. LF205887 - JP 2014500723-A/13390: Polycomb-Associated Non-Coding RNAs. MA441464 - JP 2018138019-A/13390: Polycomb-Associated Non-Coding RNAs. LF349419 - JP 2014500723-A/156922: Polycomb-Associated Non-Coding RNAs. MA584996 - JP 2018138019-A/156922: Polycomb-Associated Non-Coding RNAs. LF349420 - JP 2014500723-A/156923: Polycomb-Associated Non-Coding RNAs. MA584997 - JP 2018138019-A/156923: Polycomb-Associated Non-Coding RNAs. JD024561 - Sequence 5585 from Patent EP1572962. JD034909 - Sequence 15933 from Patent EP1572962. BC046913 - Homo sapiens tubulin tyrosine ligase, mRNA (cDNA clone IMAGE:4815653). JD056832 - Sequence 37856 from Patent EP1572962. JD088409 - Sequence 69433 from Patent EP1572962. JD088410 - Sequence 69434 from Patent EP1572962. JD138185 - Sequence 119209 from Patent EP1572962. JD175639 - Sequence 156663 from Patent EP1572962. JD331856 - Sequence 312880 from Patent EP1572962. JD182644 - Sequence 163668 from Patent EP1572962. JD084176 - Sequence 65200 from Patent EP1572962. JD246692 - Sequence 227716 from Patent EP1572962. JD100420 - Sequence 81444 from Patent EP1572962. JD057164 - Sequence 38188 from Patent EP1572962. JD405266 - Sequence 386290 from Patent EP1572962. JD189796 - Sequence 170820 from Patent EP1572962. JD050852 - Sequence 31876 from Patent EP1572962. JD318886 - Sequence 299910 from Patent EP1572962. JD364618 - Sequence 345642 from Patent EP1572962. JD381569 - Sequence 362593 from Patent EP1572962. JD367565 - Sequence 348589 from Patent EP1572962. JD367566 - Sequence 348590 from Patent EP1572962. JD059762 - Sequence 40786 from Patent EP1572962. AK096524 - Homo sapiens cDNA FLJ39205 fis, clone OCBBF2005843. JD184345 - Sequence 165369 from Patent EP1572962. JD236396 - Sequence 217420 from Patent EP1572962. JD542802 - Sequence 523826 from Patent EP1572962. JD212775 - Sequence 193799 from Patent EP1572962. JD231039 - Sequence 212063 from Patent EP1572962. JD271429 - Sequence 252453 from Patent EP1572962. JD198171 - Sequence 179195 from Patent EP1572962. JD536553 - Sequence 517577 from Patent EP1572962. JD459836 - Sequence 440860 from Patent EP1572962. JD131536 - Sequence 112560 from Patent EP1572962. JD413476 - Sequence 394500 from Patent EP1572962. JD247065 - Sequence 228089 from Patent EP1572962. JD247066 - Sequence 228090 from Patent EP1572962. JD247068 - Sequence 228092 from Patent EP1572962. JD247067 - Sequence 228091 from Patent EP1572962. JD257751 - Sequence 238775 from Patent EP1572962. DQ576923 - Homo sapiens piRNA piR-45035, complete sequence. JD430420 - Sequence 411444 from Patent EP1572962. JD557523 - Sequence 538547 from Patent EP1572962. JD564101 - Sequence 545125 from Patent EP1572962. JD557524 - Sequence 538548 from Patent EP1572962. JD529621 - Sequence 510645 from Patent EP1572962. JD529622 - Sequence 510646 from Patent EP1572962. JD529623 - Sequence 510647 from Patent EP1572962. JD170102 - Sequence 151126 from Patent EP1572962. JD170103 - Sequence 151127 from Patent EP1572962. JD170104 - Sequence 151128 from Patent EP1572962. JD170105 - Sequence 151129 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8NG68 (Reactome details) participates in the following event(s):
R-HSA-8955706 TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins