Human Gene XIRP2 (ENST00000409195.6) from GENCODE V44
Description: Homo sapiens xin actin binding repeat containing 2 (XIRP2), transcript variant 1, mRNA. (from RefSeq NM_152381)
Gencode Transcript: ENST00000409195.6
Gencode Gene: ENSG00000163092.22
Transcript (Including UTRs)
Position: hg38 chr2:166,888,480-167,259,753 Size: 371,274 Total Exon Count: 11 Strand: +
Coding Region
Position: hg38 chr2:166,903,483-167,254,126 Size: 350,644 Coding Exon Count: 9
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: XIRP2_HUMAN
DESCRIPTION: RecName: Full=Xin actin-binding repeat-containing protein 2; AltName: Full=Beta-xin; AltName: Full=Cardiomyopathy-associated protein 3; AltName: Full=Xeplin;
FUNCTION: Protects actin filaments from depolymerization.SUBUNIT: Interacts with ACTN2 (By similarity). Interacts with F- actin.SUBCELLULAR LOCATION: Cell junction. Note=Colocalizes with actin stress fibers (By similarity).DOMAIN: Xin repeats bind F-actin.MISCELLANEOUS: 'Xin' means 'heart' in Chinese.SIMILARITY: Belongs to the Xin family.SIMILARITY: Contains 28 Xin repeats.SEQUENCE CAUTION: Sequence=AAH18673.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAY24138.1; Type=Erroneous gene model prediction; Sequence=CAD38624.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAD89958.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=CAD91141.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR012510 - Actin-binding_Xin_repeat
Pfam Domains: PF08043 - Xin repeat
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on A4UGR9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
EF119718 - Homo sapiens xeplin variant 2 (CMYA3) mRNA, complete cds, alternatively spliced.EF119719 - Homo sapiens xeplin variant 2 (CMYA3) mRNA, complete cds, alternatively spliced.EF119720 - Homo sapiens xeplin variant 2 (CMYA3) mRNA, complete cds, alternatively spliced.EF119721 - Homo sapiens xeplin variant 3 (CMYA3) mRNA, complete cds, alternatively spliced.EF119722 - Homo sapiens xeplin variant 3 (CMYA3) mRNA, complete cds, alternatively spliced.AK097519 - Homo sapiens cDNA FLJ40200 fis, clone TESTI2020071.AY820969 - Homo sapiens CMYA3 mRNA, complete cds.AK122889 - Homo sapiens cDNA FLJ16539 fis, clone OCBBF2034529, moderately similar to Mus musculus xin actin-binding repeat containing 2 (Xirp2), transcript variant 1, mRNA.EF119711 - Homo sapiens beta-xin (CMYA3) mRNA, complete cds, alternatively spliced.EF119717 - Homo sapiens xeplin variant 1 (CMYA3) mRNA, complete cds, alternatively spliced.AL832331 - Homo sapiens mRNA; cDNA DKFZp451G055 (from clone DKFZp451G055).BC022887 - Homo sapiens cardiomyopathy associated 3, mRNA (cDNA clone IMAGE:4328322), partial cds.BX647848 - Homo sapiens mRNA; cDNA DKFZp451N161 (from clone DKFZp451N161).BC022446 - Homo sapiens cardiomyopathy associated 3, mRNA (cDNA clone IMAGE:4288577), partial cds.AL833291 - Homo sapiens mRNA; cDNA DKFZp451E159 (from clone DKFZp451E159).BX647448 - Homo sapiens mRNA; cDNA DKFZp451F057 (from clone DKFZp451F057).BC016370 - Homo sapiens cardiomyopathy associated 3, mRNA (cDNA clone IMAGE:4289504), partial cds.BC018673 - Homo sapiens xin actin-binding repeat containing 2, mRNA (cDNA clone IMAGE:4290750), partial cds.AJ626901 - Homo sapiens partial mRNA for XIRP2 (CMYA3 gene).AK096430 - Homo sapiens cDNA FLJ39111 fis, clone NTONG2005265.BX647844 - Homo sapiens mRNA; cDNA DKFZp451F141 (from clone DKFZp451F141).AK125495 - Homo sapiens cDNA FLJ43506 fis, clone PERIC1000147.CR627255 - Homo sapiens mRNA; cDNA DKFZp779G1747 (from clone DKFZp779G1747).AK092683 - Homo sapiens cDNA FLJ35364 fis, clone SKMUS2000726.AX747670 - Sequence 1195 from Patent EP1308459.AL832452 - Homo sapiens mRNA; cDNA DKFZp451A051 (from clone DKFZp451A051); complete cds.AL832336 - Homo sapiens mRNA; cDNA DKFZp451K165 (from clone DKFZp451K165).AL832011 - Homo sapiens mRNA; cDNA DKFZp451D064 (from clone DKFZp451D064).AK096907 - Homo sapiens cDNA FLJ39588 fis, clone SKMUS2008474.BX647645 - Homo sapiens mRNA; cDNA DKFZp451E017 (from clone DKFZp451E017).AL831970 - Homo sapiens mRNA; cDNA DKFZp451B223 (from clone DKFZp451B223).BX647845 - Homo sapiens mRNA; cDNA DKFZp451K101 (from clone DKFZp451K101).AL832360 - Homo sapiens mRNA; cDNA DKFZp451J136 (from clone DKFZp451J136).AL832382 - Homo sapiens mRNA; cDNA DKFZp451N217 (from clone DKFZp451N217).AL831985 - Homo sapiens mRNA; cDNA DKFZp451G193 (from clone DKFZp451G193).AL832375 - Homo sapiens mRNA; cDNA DKFZp451G187 (from clone DKFZp451G187).AK056582 - Homo sapiens cDNA FLJ32020 fis, clone NTONG1000123.JD333605 - Sequence 314629 from Patent EP1572962.BC070143 - Homo sapiens cardiomyopathy associated 3, mRNA (cDNA clone IMAGE:4245075).JD049195 - Sequence 30219 from Patent EP1572962.BC107799 - Homo sapiens cDNA clone IMAGE:4245336.JD296015 - Sequence 277039 from Patent EP1572962.JD477622 - Sequence 458646 from Patent EP1572962.JD114140 - Sequence 95164 from Patent EP1572962.BC022888 - Homo sapiens xin actin-binding repeat containing 2, mRNA (cDNA clone IMAGE:4338489).KJ903749 - Synthetic construct Homo sapiens clone ccsbBroadEn_13143 XIRP2 gene, encodes complete protein.JD273477 - Sequence 254501 from Patent EP1572962.JD564253 - Sequence 545277 from Patent EP1572962.JD312315 - Sequence 293339 from Patent EP1572962.JD549490 - Sequence 530514 from Patent EP1572962.JD332609 - Sequence 313633 from Patent EP1572962.JD073848 - Sequence 54872 from Patent EP1572962.AK123963 - Homo sapiens cDNA FLJ41969 fis, clone SKMUS2003074.JD209259 - Sequence 190283 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A0PJ94, A4UGR9, B2BBS0, B2BBS1, B2BBS4, B3KVH0, CMYA3, ENST00000409195.1, ENST00000409195.2, ENST00000409195.3, ENST00000409195.4, ENST00000409195.5, NM_152381, Q53R52, Q5MJ67, Q702N7, Q86T36, Q86T38, Q86T46, Q86T51, Q86T53, Q86T55, Q86T79, Q86TB6, Q8N1M9, Q8N3R5, Q8TBV6, uc002udx.1, uc002udx.2, uc002udx.3, uc002udx.4, uc002udx.5, XIRP2_HUMANUCSC ID: ENST00000409195.6RefSeq Accession: NM_152381
Protein: A4UGR9
(aka XIRP2_HUMAN)
CCDS: CCDS42769.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.