Human Gene RBM45 (ENST00000286070.10) Description and Page Index
Description: Homo sapiens RNA binding motif protein 45 (RBM45), transcript variant 1, mRNA. (from RefSeq NM_152945) RefSeq Summary (NM_152945): This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]. Gencode Transcript: ENST00000286070.10 Gencode Gene: ENSG00000155636.15 Transcript (Including UTRs) Position: hg38 chr2:178,112,437-178,129,656 Size: 17,220 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr2:178,112,547-178,126,176 Size: 13,630 Coding Exon Count: 9
ID:RBM45_HUMAN DESCRIPTION: RecName: Full=RNA-binding protein 45; AltName: Full=Developmentally-regulated RNA-binding protein 1; Short=RB-1; AltName: Full=RNA-binding motif protein 45; FUNCTION: RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IUH3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.