Human Gene RBM45 (ENST00000286070.10) Description and Page Index
  Description: Homo sapiens RNA binding motif protein 45 (RBM45), transcript variant 1, mRNA. (from RefSeq NM_152945)
RefSeq Summary (NM_152945): This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015].
Gencode Transcript: ENST00000286070.10
Gencode Gene: ENSG00000155636.15
Transcript (Including UTRs)
   Position: hg38 chr2:178,112,437-178,129,656 Size: 17,220 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr2:178,112,547-178,126,176 Size: 13,630 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:178,112,437-178,129,656)mRNA (may differ from genome)Protein (474 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=RNA-binding protein 45; AltName: Full=Developmentally-regulated RNA-binding protein 1; Short=RB-1; AltName: Full=RNA-binding motif protein 45;
FUNCTION: RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.
SIMILARITY: Contains 3 RRM (RNA recognition motif) domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.98 RPKM in Pituitary
Total median expression: 125.84 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.90110-0.435 Picture PostScript Text
3' UTR -61.10268-0.228 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

ModBase Predicted Comparative 3D Structure on Q8IUH3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0030154 cell differentiation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  LF205734 - JP 2014500723-A/13237: Polycomb-Associated Non-Coding RNAs.
MA441311 - JP 2018138019-A/13237: Polycomb-Associated Non-Coding RNAs.
AF526533 - Homo sapiens putative RNA binding protein RB-1 mRNA, complete cds.
BC066549 - Homo sapiens RNA binding motif protein 45, mRNA (cDNA clone MGC:70459 IMAGE:5748065), complete cds.
AK126575 - Homo sapiens cDNA FLJ44612 fis, clone BRACE2012625.
AB036991 - Homo sapiens drb1 mRNA for developmentally regulated RNA-binding protein 1, complete cds.
JD141479 - Sequence 122503 from Patent EP1572962.
BC037837 - Homo sapiens RNA binding motif protein 45, mRNA (cDNA clone IMAGE:4813419), with apparent retained intron.
JD213938 - Sequence 194962 from Patent EP1572962.
JD051103 - Sequence 32127 from Patent EP1572962.
CU688160 - Synthetic construct Homo sapiens gateway clone IMAGE:100022847 5' read RBM45 mRNA.
HQ447489 - Synthetic construct Homo sapiens clone IMAGE:100070822; CCSB014231_01 developmentally regulated RNA-binding protein 1 (RBM45) gene, encodes complete protein.
KJ895462 - Synthetic construct Homo sapiens clone ccsbBroadEn_04856 RBM45 gene, encodes complete protein.
LF347596 - JP 2014500723-A/155099: Polycomb-Associated Non-Coding RNAs.
MA583173 - JP 2018138019-A/155099: Polycomb-Associated Non-Coding RNAs.
LF347597 - JP 2014500723-A/155100: Polycomb-Associated Non-Coding RNAs.
MA583174 - JP 2018138019-A/155100: Polycomb-Associated Non-Coding RNAs.
LF347598 - JP 2014500723-A/155101: Polycomb-Associated Non-Coding RNAs.
MA583175 - JP 2018138019-A/155101: Polycomb-Associated Non-Coding RNAs.
JD305465 - Sequence 286489 from Patent EP1572962.
JD094636 - Sequence 75660 from Patent EP1572962.
JD471179 - Sequence 452203 from Patent EP1572962.
JD182055 - Sequence 163079 from Patent EP1572962.
JD554310 - Sequence 535334 from Patent EP1572962.
JD301134 - Sequence 282158 from Patent EP1572962.
JD566184 - Sequence 547208 from Patent EP1572962.
JD548393 - Sequence 529417 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DRB1, DRBP1, NM_152945, Q6NYL0, Q8IUH3, Q8NFC9, RBM45_HUMAN, uc002ulv.1, uc002ulv.2, uc002ulv.3, uc002ulv.4, uc002ulv.5
UCSC ID: uc002ulv.5
RefSeq Accession: NM_152945
Protein: Q8IUH3 (aka RBM45_HUMAN)
CCDS: CCDS33335.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.