Human Gene DUSP19 (ENST00000354221.5) from GENCODE V44
Description: Homo sapiens dual specificity phosphatase 19 (DUSP19), transcript variant 4, non-coding RNA. (from RefSeq NR_135688) RefSeq Summary (NM_080876): Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]. Gencode Transcript: ENST00000354221.5 Gencode Gene: ENSG00000162999.13 Transcript (Including UTRs) Position: hg38 chr2:183,078,747-183,100,008 Size: 21,262 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr2:183,078,934-183,095,658 Size: 16,725 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WTR2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0004860 protein kinase inhibitor activity GO:0005078 MAP-kinase scaffold activity GO:0005515 protein binding GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0008579 JUN kinase phosphatase activity GO:0016787 hydrolase activity GO:0016791 phosphatase activity GO:0030295 protein kinase activator activity GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process: GO:0006469 negative regulation of protein kinase activity GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation GO:0032147 activation of protein kinase activity GO:0035335 peptidyl-tyrosine dephosphorylation GO:0043410 positive regulation of MAPK cascade GO:0043507 positive regulation of JUN kinase activity GO:0043508 negative regulation of JUN kinase activity GO:0045860 positive regulation of protein kinase activity GO:0046329 negative regulation of JNK cascade GO:0046330 positive regulation of JNK cascade
Descriptions from all associated GenBank mRNAs
AB063186 - Homo sapiens hSKRP1 mRNA for SKRP1, complete cds, splice variant long form. AB063187 - Homo sapiens hSKRP1 mRNA for SKRP1, complete cds, splice variant short form. AK314078 - Homo sapiens cDNA, FLJ94749, Homo sapiens protein phosphatase (SKRP1), mRNA. BC035000 - Homo sapiens dual specificity phosphatase 19, mRNA (cDNA clone MGC:33229 IMAGE:5269106), complete cds. AF486808 - Homo sapiens dual-specificity phosphatase TS-DSP1 mRNA, complete cds. BC093958 - Homo sapiens dual specificity phosphatase 19, mRNA (cDNA clone MGC:120993 IMAGE:7939803), complete cds. BC112005 - Homo sapiens dual specificity phosphatase 19, mRNA (cDNA clone MGC:138210 IMAGE:8327473), complete cds. BC143337 - Homo sapiens cDNA clone IMAGE:9051842. JD214107 - Sequence 195131 from Patent EP1572962. AB038770 - Homo sapiens mRNA for protein phosphatase, complete cds. JD147023 - Sequence 128047 from Patent EP1572962. JD500229 - Sequence 481253 from Patent EP1572962. JD371110 - Sequence 352134 from Patent EP1572962. AB590332 - Synthetic construct DNA, clone: pFN21AE2245, Homo sapiens DUSP19 gene for dual specificity phosphatase 19, without stop codon, in Flexi system. DQ891206 - Synthetic construct clone IMAGE:100003836; FLH170152.01X; RZPDo839C0498D dual specificity phosphatase 19 (DUSP19) gene, encodes complete protein. DQ894389 - Synthetic construct Homo sapiens clone IMAGE:100008849; FLH170148.01L; RZPDo839C0497D dual specificity phosphatase 19 (DUSP19) gene, encodes complete protein. KJ895566 - Synthetic construct Homo sapiens clone ccsbBroadEn_04960 DUSP19 gene, encodes complete protein. BX647818 - Homo sapiens mRNA; cDNA DKFZp686B2086 (from clone DKFZp686B2086). JD393268 - Sequence 374292 from Patent EP1572962. JD530332 - Sequence 511356 from Patent EP1572962. JD263741 - Sequence 244765 from Patent EP1572962. JD350550 - Sequence 331574 from Patent EP1572962. AK125657 - Homo sapiens cDNA FLJ43669 fis, clone SYNOV4007430. JD563432 - Sequence 544456 from Patent EP1572962. JD534137 - Sequence 515161 from Patent EP1572962. JD383773 - Sequence 364797 from Patent EP1572962. JD070051 - Sequence 51075 from Patent EP1572962. JD535809 - Sequence 516833 from Patent EP1572962. JD563656 - Sequence 544680 from Patent EP1572962. JD198387 - Sequence 179411 from Patent EP1572962. JD153111 - Sequence 134135 from Patent EP1572962. JD066588 - Sequence 47612 from Patent EP1572962. JD275419 - Sequence 256443 from Patent EP1572962. JD039519 - Sequence 20543 from Patent EP1572962. JD307427 - Sequence 288451 from Patent EP1572962. JD057003 - Sequence 38027 from Patent EP1572962. JD525897 - Sequence 506921 from Patent EP1572962. JD245514 - Sequence 226538 from Patent EP1572962. JD565988 - Sequence 547012 from Patent EP1572962. JD280562 - Sequence 261586 from Patent EP1572962. JD441154 - Sequence 422178 from Patent EP1572962. JD373382 - Sequence 354406 from Patent EP1572962. JD107871 - Sequence 88895 from Patent EP1572962. JD521096 - Sequence 502120 from Patent EP1572962. JD146255 - Sequence 127279 from Patent EP1572962. JD508395 - Sequence 489419 from Patent EP1572962. JD460134 - Sequence 441158 from Patent EP1572962. JD397323 - Sequence 378347 from Patent EP1572962. JD538715 - Sequence 519739 from Patent EP1572962. JD505209 - Sequence 486233 from Patent EP1572962. JD269215 - Sequence 250239 from Patent EP1572962. JD309766 - Sequence 290790 from Patent EP1572962. AK094800 - Homo sapiens cDNA FLJ37481 fis, clone BRAWH2013914. JD335046 - Sequence 316070 from Patent EP1572962. JD176162 - Sequence 157186 from Patent EP1572962. JD559331 - Sequence 540355 from Patent EP1572962. JD435411 - Sequence 416435 from Patent EP1572962. JD308110 - Sequence 289134 from Patent EP1572962. JD308111 - Sequence 289135 from Patent EP1572962. JD294967 - Sequence 275991 from Patent EP1572962. JD488104 - Sequence 469128 from Patent EP1572962. JD414968 - Sequence 395992 from Patent EP1572962. JD346676 - Sequence 327700 from Patent EP1572962. JD058063 - Sequence 39087 from Patent EP1572962. JD233517 - Sequence 214541 from Patent EP1572962. JD549508 - Sequence 530532 from Patent EP1572962. JD349769 - Sequence 330793 from Patent EP1572962. JD083916 - Sequence 64940 from Patent EP1572962. JD299652 - Sequence 280676 from Patent EP1572962. JD287698 - Sequence 268722 from Patent EP1572962. JD170689 - Sequence 151713 from Patent EP1572962. JD508932 - Sequence 489956 from Patent EP1572962. JD536937 - Sequence 517961 from Patent EP1572962. JD302140 - Sequence 283164 from Patent EP1572962. JD129874 - Sequence 110898 from Patent EP1572962. JD409751 - Sequence 390775 from Patent EP1572962. JD500053 - Sequence 481077 from Patent EP1572962. JD288480 - Sequence 269504 from Patent EP1572962. JD249783 - Sequence 230807 from Patent EP1572962. JD537264 - Sequence 518288 from Patent EP1572962. JD380857 - Sequence 361881 from Patent EP1572962. JD247231 - Sequence 228255 from Patent EP1572962. JD279191 - Sequence 260215 from Patent EP1572962. JD223276 - Sequence 204300 from Patent EP1572962. JD220278 - Sequence 201302 from Patent EP1572962. JD238479 - Sequence 219503 from Patent EP1572962. JD472581 - Sequence 453605 from Patent EP1572962. JD063484 - Sequence 44508 from Patent EP1572962. JD430750 - Sequence 411774 from Patent EP1572962. JD264407 - Sequence 245431 from Patent EP1572962. JD439864 - Sequence 420888 from Patent EP1572962. JD277359 - Sequence 258383 from Patent EP1572962. JD481884 - Sequence 462908 from Patent EP1572962. JD446716 - Sequence 427740 from Patent EP1572962. JD138135 - Sequence 119159 from Patent EP1572962. JD175510 - Sequence 156534 from Patent EP1572962. JD507965 - Sequence 488989 from Patent EP1572962. JD067638 - Sequence 48662 from Patent EP1572962.