Human Gene OSGEPL1 (ENST00000264151.10) from GENCODE V44
  Description: Homo sapiens O-sialoglycoprotein endopeptidase like 1 (OSGEPL1), transcript variant 23, non-coding RNA. (from RefSeq NR_164769)
Gencode Transcript: ENST00000264151.10
Gencode Gene: ENSG00000128694.12
Transcript (Including UTRs)
   Position: hg38 chr2:189,746,660-189,762,792 Size: 16,133 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr2:189,750,578-189,761,640 Size: 11,063 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:189,746,660-189,762,792)mRNA (may differ from genome)Protein (414 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OSGP2_HUMAN
DESCRIPTION: RecName: Full=Probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1; AltName: Full=t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1;
FUNCTION: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity).
SIMILARITY: Belongs to the KAE1 / YgjD family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.60 RPKM in Adrenal Gland
Total median expression: 136.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.60128-0.325 Picture PostScript Text
3' UTR -111.00537-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000905 - Gcp-like_dom
IPR017861 - KAE1/YgjD

Pfam Domains:
PF00814 - Glycoprotease family

ModBase Predicted Comparative 3D Structure on Q9H4B0
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004222 metalloendopeptidase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding
GO:0061711 N(6)-L-threonylcarbamoyladenine synthase

Biological Process:
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0006508 proteolysis
GO:0008033 tRNA processing

Cellular Component:
GO:0000408 EKC/KEOPS complex
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  BC011904 - Homo sapiens O-sialoglycoprotein endopeptidase-like 1, mRNA (cDNA clone MGC:20293 IMAGE:4121450), complete cds.
BC035835 - Homo sapiens, clone IMAGE:5589958, mRNA.
AK055441 - Homo sapiens cDNA FLJ30879 fis, clone FEBRA2004592, highly similar to Homo sapiens mRNA for putative sialoglycoprotease type 2.
AJ295148 - Homo sapiens mRNA for putative sialoglycoprotease type 2.
AK314565 - Homo sapiens cDNA, FLJ95389.
KJ904849 - Synthetic construct Homo sapiens clone ccsbBroadEn_14243 OSGEPL1-like gene, encodes complete protein.
DQ893047 - Synthetic construct clone IMAGE:100005677; FLH192990.01X; RZPDo839B0778D O-sialoglycoprotein endopeptidase-like 1 (OSGEPL1) gene, encodes complete protein.
DQ896291 - Synthetic construct Homo sapiens clone IMAGE:100010751; FLH192986.01L; RZPDo839B0768D O-sialoglycoprotein endopeptidase-like 1 (OSGEPL1) gene, encodes complete protein.
AK294841 - Homo sapiens cDNA FLJ60510 complete cds, highly similar to Homo sapiens O-sialoglycoprotein endopeptidase-like 1 (OSGEPL1), mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000264151.1, ENST00000264151.2, ENST00000264151.3, ENST00000264151.4, ENST00000264151.5, ENST00000264151.6, ENST00000264151.7, ENST00000264151.8, ENST00000264151.9, NR_164769, OSGP2_HUMAN, Q96EV9, Q96NH5, Q9H4B0, uc002uqz.1, uc002uqz.2, uc002uqz.3
UCSC ID: ENST00000264151.10
RefSeq Accession: NM_022353
Protein: Q9H4B0 (aka OSGP2_HUMAN)
CCDS: CCDS46472.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.