Human Gene CYP20A1 (ENST00000356079.9) from GENCODE V44
  Description: Homo sapiens cytochrome P450 family 20 subfamily A member 1 (CYP20A1), transcript variant 18, non-coding RNA. (from RefSeq NR_163985)
RefSeq Summary (NM_177538): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Gencode Transcript: ENST00000356079.9
Gencode Gene: ENSG00000119004.17
Transcript (Including UTRs)
   Position: hg38 chr2:203,239,018-203,306,026 Size: 67,009 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr2:203,239,063-203,296,908 Size: 57,846 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:203,239,018-203,306,026)mRNA (may differ from genome)Protein (462 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGencode
GeneCardsHGNCHPRDLynxMalacardsMGI
neXtProtPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CP20A_HUMAN
DESCRIPTION: RecName: Full=Cytochrome P450 20A1; EC=1.14.-.-;
CATALYTIC ACTIVITY: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
COFACTOR: Heme group (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the cytochrome P450 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.30 RPKM in Testis
Total median expression: 130.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.1045-0.291 Picture PostScript Text
3' UTR -3981.509118-0.437 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001128 - Cyt_P450
IPR002401 - Cyt_P450_E_grp-I

Pfam Domains:
PF00067 - Cytochrome P450

ModBase Predicted Comparative 3D Structure on Q6UW02
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

Biological Process:
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ899330 - Synthetic construct Homo sapiens clone ccsbBroadEn_08724 CYP20A1 gene, encodes complete protein.
KJ899331 - Synthetic construct Homo sapiens clone ccsbBroadEn_08725 CYP20A1 gene, encodes complete protein.
AF183412 - Homo sapiens cytochrome P450 monooxygenase mRNA, complete cds.
BC093022 - Homo sapiens cytochrome P450, family 20, subfamily A, polypeptide 1, mRNA (cDNA clone IMAGE:30348208), partial cds.
AK297082 - Homo sapiens cDNA FLJ59248 complete cds, highly similar to Homo sapiens cytochrome P450, family 20, subfamily A, polypeptide 1, transcript variant 1, mRNA.
BC033752 - Homo sapiens cytochrome P450, family 20, subfamily A, polypeptide 1, mRNA (cDNA clone MGC:45025 IMAGE:5211537), complete cds.
BC020616 - Homo sapiens cytochrome P450, family 20, subfamily A, polypeptide 1, mRNA (cDNA clone MGC:22229 IMAGE:4689065), complete cds.
AY359068 - Homo sapiens clone DNA66512 P450-like protein (UNQ667) mRNA, complete cds.
AL832998 - Homo sapiens mRNA; cDNA DKFZp666P073 (from clone DKFZp666P073).
AK307931 - Homo sapiens cDNA, FLJ97879.
DQ894068 - Synthetic construct Homo sapiens clone IMAGE:100008528; FLH263721.01L; RZPDo839H0387D cytochrome P450, family 20, subfamily A, polypeptide 1 (CYP20A1) gene, encodes complete protein.
DQ894069 - Synthetic construct Homo sapiens clone IMAGE:100008529; FLH167084.01L; RZPDo839H0487D cytochrome P450, family 20, subfamily A, polypeptide 1 (CYP20A1) gene, encodes complete protein.
DQ890918 - Synthetic construct clone IMAGE:100003548; FLH167088.01X; RZPDo839H0488D cytochrome P450, family 20, subfamily A, polypeptide 1 (CYP20A1) gene, encodes complete protein.
AF289579 - Homo sapiens clone pp7105 unknown mRNA.
CU676580 - Synthetic construct Homo sapiens gateway clone IMAGE:100022328 5' read CYP20A1 mRNA.
JD181697 - Sequence 162721 from Patent EP1572962.
JD288018 - Sequence 269042 from Patent EP1572962.
JD447992 - Sequence 429016 from Patent EP1572962.
JD272013 - Sequence 253037 from Patent EP1572962.
JD516946 - Sequence 497970 from Patent EP1572962.
AK021770 - Homo sapiens cDNA FLJ11708 fis, clone HEMBA1005123.
JD223926 - Sequence 204950 from Patent EP1572962.
JD238256 - Sequence 219280 from Patent EP1572962.
JD140075 - Sequence 121099 from Patent EP1572962.
JD220326 - Sequence 201350 from Patent EP1572962.
JD196117 - Sequence 177141 from Patent EP1572962.
JD142533 - Sequence 123557 from Patent EP1572962.
JD222877 - Sequence 203901 from Patent EP1572962.
JD222878 - Sequence 203902 from Patent EP1572962.
JD266428 - Sequence 247452 from Patent EP1572962.
DQ595978 - Homo sapiens piRNA piR-34044, complete sequence.
JD472505 - Sequence 453529 from Patent EP1572962.
JD421967 - Sequence 402991 from Patent EP1572962.
JD212415 - Sequence 193439 from Patent EP1572962.
JD197806 - Sequence 178830 from Patent EP1572962.
JD412786 - Sequence 393810 from Patent EP1572962.
JD512754 - Sequence 493778 from Patent EP1572962.
JD097677 - Sequence 78701 from Patent EP1572962.
JD135914 - Sequence 116938 from Patent EP1572962.
JD194719 - Sequence 175743 from Patent EP1572962.
JD144128 - Sequence 125152 from Patent EP1572962.
JD092546 - Sequence 73570 from Patent EP1572962.
JD481537 - Sequence 462561 from Patent EP1572962.
JD321290 - Sequence 302314 from Patent EP1572962.
JD388925 - Sequence 369949 from Patent EP1572962.
JD560783 - Sequence 541807 from Patent EP1572962.
JD441305 - Sequence 422329 from Patent EP1572962.
JD441306 - Sequence 422330 from Patent EP1572962.
JD328765 - Sequence 309789 from Patent EP1572962.
JD328766 - Sequence 309790 from Patent EP1572962.
JD328768 - Sequence 309792 from Patent EP1572962.
JD452280 - Sequence 433304 from Patent EP1572962.
JD221888 - Sequence 202912 from Patent EP1572962.
JD229825 - Sequence 210849 from Patent EP1572962.
JD378239 - Sequence 359263 from Patent EP1572962.
JD455086 - Sequence 436110 from Patent EP1572962.
JD537332 - Sequence 518356 from Patent EP1572962.
JD194729 - Sequence 175753 from Patent EP1572962.
JD100555 - Sequence 81579 from Patent EP1572962.
JD135926 - Sequence 116950 from Patent EP1572962.
JD293527 - Sequence 274551 from Patent EP1572962.
JD389021 - Sequence 370045 from Patent EP1572962.
JD389022 - Sequence 370046 from Patent EP1572962.
JD070140 - Sequence 51164 from Patent EP1572962.
JD564529 - Sequence 545553 from Patent EP1572962.
JD194817 - Sequence 175841 from Patent EP1572962.
JD194818 - Sequence 175842 from Patent EP1572962.
JD136075 - Sequence 117099 from Patent EP1572962.
JD136074 - Sequence 117098 from Patent EP1572962.
JD041378 - Sequence 22402 from Patent EP1572962.
JD169358 - Sequence 150382 from Patent EP1572962.
JD321125 - Sequence 302149 from Patent EP1572962.
JD374550 - Sequence 355574 from Patent EP1572962.
JD384796 - Sequence 365820 from Patent EP1572962.
JD489177 - Sequence 470201 from Patent EP1572962.
JD441161 - Sequence 422185 from Patent EP1572962.
JD120535 - Sequence 101559 from Patent EP1572962.
JD379622 - Sequence 360646 from Patent EP1572962.
JD094095 - Sequence 75119 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CP20A_HUMAN, ENST00000356079.1, ENST00000356079.2, ENST00000356079.3, ENST00000356079.4, ENST00000356079.5, ENST00000356079.6, ENST00000356079.7, ENST00000356079.8, NR_163985, Q4ZG61, Q6UW02, Q8N4Q8, Q8WWA9, uc002uzv.1, uc002uzv.2, uc002uzv.3, uc002uzv.4, uc002uzv.5, uc002uzv.6, UNQ667/PRO1301
UCSC ID: ENST00000356079.9
RefSeq Accession: NM_177538
Protein: Q6UW02 (aka CP20A_HUMAN)
CCDS: CCDS2357.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.