Human Gene MAP2 (ENST00000361559.8) from GENCODE V44
Description: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. (from UniProt P11137) RefSeq Summary (NM_031845): This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]. Gencode Transcript: ENST00000361559.8 Gencode Gene: ENSG00000078018.22 Transcript (Including UTRs) Position: hg38 chr2:209,579,431-209,730,523 Size: 151,093 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr2:209,653,171-209,730,397 Size: 77,227 Coding Exon Count: 9
ID:MAP2_HUMAN DESCRIPTION: RecName: Full=Microtubule-associated protein 2; Short=MAP-2; FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. INTERACTION: Q13951:CBFB; NbExp=2; IntAct=EBI-2682460, EBI-718750; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). PTM: Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Isoform MAP2c is phosphorylated by FYN at Tyr-67. SIMILARITY: Contains 3 Tau/MAP repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08377 - MAP2/Tau projection domain PF00418 - Tau and MAP protein, tubulin-binding repeat
ModBase Predicted Comparative 3D Structure on P11137
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0001578 microtubule bundle formation GO:0007409 axonogenesis GO:0016358 dendrite development GO:0021954 central nervous system neuron development GO:0030010 establishment of cell polarity GO:0030517 negative regulation of axon extension GO:0031113 regulation of microtubule polymerization GO:0031115 negative regulation of microtubule polymerization GO:0031175 neuron projection development GO:0048813 dendrite morphogenesis GO:0050770 regulation of axonogenesis GO:0071310 cellular response to organic substance GO:1901953 positive regulation of anterograde dense core granule transport GO:1902513 regulation of organelle transport along microtubule GO:1903744 positive regulation of anterograde synaptic vesicle transport GO:1903827 regulation of cellular protein localization GO:1904527 negative regulation of microtubule binding GO:2000575 negative regulation of microtubule motor activity
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