Human Gene KANSL1L (ENST00000281772.14) from GENCODE V44
  Description: Homo sapiens KAT8 regulatory NSL complex subunit 1 like (KANSL1L), transcript variant 1, mRNA. (from RefSeq NM_152519)
Gencode Transcript: ENST00000281772.14
Gencode Gene: ENSG00000144445.17
Transcript (Including UTRs)
   Position: hg38 chr2:210,021,421-210,171,409 Size: 149,989 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg38 chr2:210,022,949-210,154,582 Size: 131,634 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:210,021,421-210,171,409)mRNA (may differ from genome)Protein (987 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KAL1L_HUMAN
DESCRIPTION: RecName: Full=KAT8 regulatory NSL complex subunit 1-like protein; AltName: Full=MSL1v2;
SEQUENCE CAUTION: Sequence=BAB85085.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB85085.1; Type=Erroneous termination; Positions=914; Note=Translated as Trp; Sequence=BAB85085.1; Type=Frameshift; Positions=496, 502, 550, 553, 673, 676, 755, 757, 853;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.63 RPKM in Nerve - Tibial
Total median expression: 192.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -157.50290-0.543 Picture PostScript Text
3' UTR -308.801528-0.202 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026180 - NSL1

ModBase Predicted Comparative 3D Structure on A0AUZ9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0000123 histone acetyltransferase complex


-  Descriptions from all associated GenBank mRNAs
  AK074441 - Homo sapiens cDNA FLJ23861 fis, clone LNG08328.
BC090854 - Homo sapiens hypothetical protein FLJ23861, mRNA (cDNA clone IMAGE:6197078).
BC126155 - Homo sapiens chromosome 2 open reading frame 67, mRNA (cDNA clone MGC:161433 IMAGE:8991871), complete cds.
BC143914 - Homo sapiens chromosome 2 open reading frame 67, mRNA (cDNA clone MGC:177449 IMAGE:9052432), complete cds.
HQ258521 - Synthetic construct Homo sapiens clone IMAGE:100072950 Unknown protein gene, encodes complete protein.
KJ903876 - Synthetic construct Homo sapiens clone ccsbBroadEn_13270 KANSL1L gene, encodes complete protein.
BC032837 - Homo sapiens chromosome 2 open reading frame 67, mRNA (cDNA clone MGC:27010 IMAGE:4829661), complete cds.
AK056911 - Homo sapiens cDNA FLJ32349 fis, clone PROST2007237.
KJ903875 - Synthetic construct Homo sapiens clone ccsbBroadEn_13269 KANSL1L gene, encodes complete protein.
BC070141 - Homo sapiens chromosome 2 open reading frame 67, mRNA (cDNA clone IMAGE:6615864), partial cds.
JD344990 - Sequence 326014 from Patent EP1572962.
JD283988 - Sequence 265012 from Patent EP1572962.
JD167579 - Sequence 148603 from Patent EP1572962.
JD553469 - Sequence 534493 from Patent EP1572962.
JD505059 - Sequence 486083 from Patent EP1572962.
AL133053 - Homo sapiens mRNA; cDNA DKFZp434H1215 (from clone DKFZp434H1215); partial cds.
JD186061 - Sequence 167085 from Patent EP1572962.
JD253754 - Sequence 234778 from Patent EP1572962.
JD126607 - Sequence 107631 from Patent EP1572962.
JD239118 - Sequence 220142 from Patent EP1572962.
JD089820 - Sequence 70844 from Patent EP1572962.
JD539165 - Sequence 520189 from Patent EP1572962.
JD331485 - Sequence 312509 from Patent EP1572962.
JD302187 - Sequence 283211 from Patent EP1572962.
JD433132 - Sequence 414156 from Patent EP1572962.
JD199863 - Sequence 180887 from Patent EP1572962.
JD200761 - Sequence 181785 from Patent EP1572962.
JD282400 - Sequence 263424 from Patent EP1572962.
JD363484 - Sequence 344508 from Patent EP1572962.
JD104858 - Sequence 85882 from Patent EP1572962.
JD165837 - Sequence 146861 from Patent EP1572962.
AK124963 - Homo sapiens cDNA FLJ42973 fis, clone BRTHA2001462.
AK124324 - Homo sapiens cDNA FLJ42333 fis, clone TUTER1000122.
AK308432 - Homo sapiens cDNA, FLJ98380.

-  Other Names for This Gene
  Alternate Gene Symbols: A0AUZ9, B7ZLN1, C2orf67, ENST00000281772.1, ENST00000281772.10, ENST00000281772.11, ENST00000281772.12, ENST00000281772.13, ENST00000281772.2, ENST00000281772.3, ENST00000281772.4, ENST00000281772.5, ENST00000281772.6, ENST00000281772.7, ENST00000281772.8, ENST00000281772.9, KAL1L_HUMAN, NM_152519, Q53TV8, Q53TW3, Q6IS05, Q8TCI1, Q96MI0, Q9UFC3, uc002vds.1, uc002vds.2, uc002vds.3, uc002vds.4, uc002vds.5
UCSC ID: ENST00000281772.14
RefSeq Accession: NM_152519
Protein: A0AUZ9 (aka KAL1L_HUMAN)
CCDS: CCDS33370.1, CCDS77519.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.