Human Gene TMBIM1 (ENST00000444881.5) from GENCODE V44
Description: Homo sapiens transmembrane BAX inhibitor motif containing 1 (TMBIM1), transcript variant 2, mRNA. (from RefSeq NM_001321427)
Gencode Transcript: ENST00000444881.5
Gencode Gene: ENSG00000135926.15
Transcript (Including UTRs)
Position: hg38 chr2:218,274,201-218,286,849 Size: 12,649 Total Exon Count: 13 Strand: -
Coding Region
Position: hg38 chr2:218,275,475-218,282,141 Size: 6,667 Coding Exon Count: 11
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: LFG3_HUMAN
DESCRIPTION: RecName: Full=Protein lifeguard 3; AltName: Full=Protein RECS1 homolog; AltName: Full=Transmembrane BAX inhibitor motif-containing protein 1;
FUNCTION: Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). Lysosome membrane. Endosome membrane.SIMILARITY: Belongs to the BI1 family. LFG subfamily.SEQUENCE CAUTION: Sequence=AAH26693.1; Type=Frameshift; Positions=6; Sequence=BAB55346.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11636.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006214 - Bax_inhibitor_1-related
Pfam Domains: PF01027 - Inhibitor of apoptosis-promoting Bax1
ModBase Predicted Comparative 3D Structure on Q969X1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC007980 - Homo sapiens transmembrane BAX inhibitor motif containing 1, mRNA (cDNA clone MGC:16253 IMAGE:3689664), complete cds.LF318574 - JP 2014500723-A/126077: Polycomb-Associated Non-Coding RNAs.MA554151 - JP 2018138019-A/126077: Polycomb-Associated Non-Coding RNAs.AF173384 - Homo sapiens MSTP100 (MST100) mRNA, complete cds.AF193045 - Homo sapiens PP1201 mRNA, complete cds.BC026348 - Homo sapiens transmembrane BAX inhibitor motif containing 1, mRNA (cDNA clone MGC:26792 IMAGE:4792398), complete cds.BC026693 - Homo sapiens transmembrane BAX inhibitor motif containing 1, mRNA (cDNA clone IMAGE:3845817), partial cds.BC013428 - Homo sapiens transmembrane BAX inhibitor motif containing 1, mRNA (cDNA clone MGC:10113 IMAGE:3899632), complete cds.LF205246 - JP 2014500723-A/12749: Polycomb-Associated Non-Coding RNAs.MA440823 - JP 2018138019-A/12749: Polycomb-Associated Non-Coding RNAs.AK075465 - Homo sapiens cDNA PSEC0158 fis, clone PLACE1008738, moderately similar to PP1201 protein.AK027755 - Homo sapiens cDNA FLJ14849 fis, clone PLACE1000611, weakly similar to Rattus norvegicus neural membrane protein 35 mRNA.AK093911 - Homo sapiens cDNA FLJ36592 fis, clone TRACH2014046, highly similar to Transmembrane BAX inhibitor motif-containing protein 1.AB257295 - Homo sapiens RECS1 mRNA for responsive to centrifugal force and shear stress gene 1, complete cds.AK090618 - Homo sapiens cDNA FLJ33299 fis, clone BNGH42001724, highly similar to Transmembrane BAX inhibitor motif-containing protein 1.AK095270 - Homo sapiens cDNA FLJ37951 fis, clone CTONG2009257, weakly similar to Rattus norvegicus neural membrane protein 35 mRNA.AK130713 - Homo sapiens cDNA FLJ27203 fis, clone SYN03168.AK130380 - Homo sapiens cDNA FLJ26870 fis, clone PRS08714.LF213695 - JP 2014500723-A/21198: Polycomb-Associated Non-Coding RNAs.MA449272 - JP 2018138019-A/21198: Polycomb-Associated Non-Coding RNAs.LF318575 - JP 2014500723-A/126078: Polycomb-Associated Non-Coding RNAs.MA554152 - JP 2018138019-A/126078: Polycomb-Associated Non-Coding RNAs.JD259227 - Sequence 240251 from Patent EP1572962.JD376861 - Sequence 357885 from Patent EP1572962.JD122632 - Sequence 103656 from Patent EP1572962.LF318576 - JP 2014500723-A/126079: Polycomb-Associated Non-Coding RNAs.MA554153 - JP 2018138019-A/126079: Polycomb-Associated Non-Coding RNAs.JD469236 - Sequence 450260 from Patent EP1572962.JD521625 - Sequence 502649 from Patent EP1572962.JD440845 - Sequence 421869 from Patent EP1572962.LF318577 - JP 2014500723-A/126080: Polycomb-Associated Non-Coding RNAs.MA554154 - JP 2018138019-A/126080: Polycomb-Associated Non-Coding RNAs.JD019874 - Sequence 898 from Patent EP1572962.JD035147 - Sequence 16171 from Patent EP1572962.JD253200 - Sequence 234224 from Patent EP1572962.JD316928 - Sequence 297952 from Patent EP1572962.JD115302 - Sequence 96326 from Patent EP1572962.JD201908 - Sequence 182932 from Patent EP1572962.JD539136 - Sequence 520160 from Patent EP1572962.JD378486 - Sequence 359510 from Patent EP1572962.JD187898 - Sequence 168922 from Patent EP1572962.JD333897 - Sequence 314921 from Patent EP1572962.JD508644 - Sequence 489668 from Patent EP1572962.JD064211 - Sequence 45235 from Patent EP1572962.AK298500 - Homo sapiens cDNA FLJ54055 complete cds, highly similar to Transmembrane BAX inhibitor motif-containing protein 1.JD387158 - Sequence 368182 from Patent EP1572962.JD487034 - Sequence 468058 from Patent EP1572962.JD113671 - Sequence 94695 from Patent EP1572962.JD321299 - Sequence 302323 from Patent EP1572962.LF318578 - JP 2014500723-A/126081: Polycomb-Associated Non-Coding RNAs.MA554155 - JP 2018138019-A/126081: Polycomb-Associated Non-Coding RNAs.JD061372 - Sequence 42396 from Patent EP1572962.JD146264 - Sequence 127288 from Patent EP1572962.JD219271 - Sequence 200295 from Patent EP1572962.AK298123 - Homo sapiens cDNA FLJ53633 complete cds, highly similar to Transmembrane BAX inhibitor motif-containing protein 1.JD477165 - Sequence 458189 from Patent EP1572962.JD488382 - Sequence 469406 from Patent EP1572962.JD445795 - Sequence 426819 from Patent EP1572962.JD507554 - Sequence 488578 from Patent EP1572962.JD361546 - Sequence 342570 from Patent EP1572962.JD288783 - Sequence 269807 from Patent EP1572962.JD525636 - Sequence 506660 from Patent EP1572962.JD139382 - Sequence 120406 from Patent EP1572962.JD287334 - Sequence 268358 from Patent EP1572962.AK300597 - Homo sapiens cDNA FLJ53658 complete cds, highly similar to Transmembrane BAX inhibitor motif-containing protein 1.JD191016 - Sequence 172040 from Patent EP1572962.LF318579 - JP 2014500723-A/126082: Polycomb-Associated Non-Coding RNAs.MA554156 - JP 2018138019-A/126082: Polycomb-Associated Non-Coding RNAs.KJ906293 - Synthetic construct Homo sapiens clone ccsbBroadEn_15963 TMBIM1 gene, encodes complete protein.DQ890999 - Synthetic construct clone IMAGE:100003629; FLH168393.01X; RZPDo839G0492D transmembrane BAX inhibitor motif containing 1 (TMBIM1) gene, encodes complete protein.KJ899442 - Synthetic construct Homo sapiens clone ccsbBroadEn_08836 TMBIM1 gene, encodes complete protein.DQ893782 - Synthetic construct Homo sapiens clone IMAGE:100008242; FLH168389.01L; RZPDo839G0491D transmembrane BAX inhibitor motif containing 1 (TMBIM1) gene, encodes complete protein.LF318580 - JP 2014500723-A/126083: Polycomb-Associated Non-Coding RNAs.MA554157 - JP 2018138019-A/126083: Polycomb-Associated Non-Coding RNAs.CU680610 - Synthetic construct Homo sapiens gateway clone IMAGE:100020691 5' read TMBIM1 mRNA.JD390410 - Sequence 371434 from Patent EP1572962.JD489509 - Sequence 470533 from Patent EP1572962.LF318586 - JP 2014500723-A/126089: Polycomb-Associated Non-Coding RNAs.MA554163 - JP 2018138019-A/126089: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: B3KQY6, ENST00000444881.1, ENST00000444881.2, ENST00000444881.3, ENST00000444881.4, LFG3, LFG3_HUMAN, NM_001321427, PP1201, PSEC0158, Q8N1R3, Q8TAM3, Q969X1, Q96K13, RECS1, uc002vho.1, uc002vho.2UCSC ID: ENST00000444881.5RefSeq Accession: NM_001321427
Protein: Q969X1
(aka LFG3_HUMAN)
CCDS: CCDS2412.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.