Human Gene FAM124B (ENST00000389874.3) from GENCODE V44
  Description: Homo sapiens family with sequence similarity 124 member B (FAM124B), transcript variant 2, mRNA. (from RefSeq NM_024785)
Gencode Transcript: ENST00000389874.3
Gencode Gene: ENSG00000124019.10
Transcript (Including UTRs)
   Position: hg38 chr2:224,378,698-224,401,994 Size: 23,297 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr2:224,400,419-224,401,768 Size: 1,350 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:224,378,698-224,401,994)mRNA (may differ from genome)Protein (272 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F124B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM124B;
INTERACTION: Q99750:MDFI; NbExp=4; IntAct=EBI-741626, EBI-724076;
SIMILARITY: Belongs to the FAM124 family.
SEQUENCE CAUTION: Sequence=BAB15471.1; Type=Frameshift; Positions=264;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FAM124B
Diseases sorted by gene-association score: charge syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.56 RPKM in Adipose - Subcutaneous
Total median expression: 23.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.80226-0.335 Picture PostScript Text
3' UTR -456.301549-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9H5Z6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  BC025754 - Homo sapiens family with sequence similarity 124B, mRNA (cDNA clone MGC:34161 IMAGE:5202295), complete cds.
AK026399 - Homo sapiens cDNA: FLJ22746 fis, clone HUV01174.
AK075126 - Homo sapiens cDNA FLJ90645 fis, clone PLACE1004199.
JD164605 - Sequence 145629 from Patent EP1572962.
JD538726 - Sequence 519750 from Patent EP1572962.
JD060327 - Sequence 41351 from Patent EP1572962.
JD403583 - Sequence 384607 from Patent EP1572962.
JD160271 - Sequence 141295 from Patent EP1572962.
JD540459 - Sequence 521483 from Patent EP1572962.
JD538914 - Sequence 519938 from Patent EP1572962.
JD373743 - Sequence 354767 from Patent EP1572962.
JD155578 - Sequence 136602 from Patent EP1572962.
JD137224 - Sequence 118248 from Patent EP1572962.
JD227330 - Sequence 208354 from Patent EP1572962.
JD193477 - Sequence 174501 from Patent EP1572962.
JD334368 - Sequence 315392 from Patent EP1572962.
JD285339 - Sequence 266363 from Patent EP1572962.
JD093394 - Sequence 74418 from Patent EP1572962.
JD330388 - Sequence 311412 from Patent EP1572962.
JD407966 - Sequence 388990 from Patent EP1572962.
JD159389 - Sequence 140413 from Patent EP1572962.
JD188289 - Sequence 169313 from Patent EP1572962.
JD041247 - Sequence 22271 from Patent EP1572962.
JD339779 - Sequence 320803 from Patent EP1572962.
JD065520 - Sequence 46544 from Patent EP1572962.
JD107854 - Sequence 88878 from Patent EP1572962.
JD119237 - Sequence 100261 from Patent EP1572962.
JD275505 - Sequence 256529 from Patent EP1572962.
JD530798 - Sequence 511822 from Patent EP1572962.
HQ447160 - Synthetic construct Homo sapiens clone IMAGE:100070448; CCSB008273_01 family with sequence similarity 124B (FAM124B) gene, encodes complete protein.
KJ894742 - Synthetic construct Homo sapiens clone ccsbBroadEn_04136 FAM124B gene, encodes complete protein.
CU693050 - Synthetic construct Homo sapiens gateway clone IMAGE:100016944 5' read FAM124B mRNA.
JD168844 - Sequence 149868 from Patent EP1572962.
JD142786 - Sequence 123810 from Patent EP1572962.
JD232909 - Sequence 213933 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NNC7, ENST00000389874.1, ENST00000389874.2, F124B_HUMAN, NM_024785, Q8NBZ4, Q8TAV7, Q9H5Z6, uc002vnw.1, uc002vnw.2, uc002vnw.3
UCSC ID: ENST00000389874.3
RefSeq Accession: NM_024785
Protein: Q9H5Z6 (aka F124B_HUMAN)
CCDS: CCDS2461.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.