Human Gene NPPC (ENST00000409852.2) from GENCODE V44
Description: Homo sapiens natriuretic peptide C (NPPC), mRNA. (from RefSeq NM_024409) RefSeq Summary (NM_024409): This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]. Gencode Transcript: ENST00000409852.2 Gencode Gene: ENSG00000163273.4 Transcript (Including UTRs) Position: hg38 chr2:231,921,809-231,926,396 Size: 4,588 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr2:231,925,425-231,926,249 Size: 825 Coding Exon Count: 2
ID:ANFC_HUMAN DESCRIPTION: RecName: Full=C-type natriuretic peptide; Contains: RecName: Full=CNP-22; Contains: RecName: Full=CNP-29; Contains: RecName: Full=CNP-53; Flags: Precursor; FUNCTION: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the natriuretic peptide family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23582
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001503 ossification GO:0001666 response to hypoxia GO:0003418 growth plate cartilage chondrocyte differentiation GO:0003419 growth plate cartilage chondrocyte proliferation GO:0006182 cGMP biosynthetic process GO:0006457 protein folding GO:0007168 receptor guanylyl cyclase signaling pathway GO:0008285 negative regulation of cell proliferation GO:0009791 post-embryonic development GO:0010469 regulation of receptor activity GO:0022414 reproductive process GO:0030814 regulation of cAMP metabolic process GO:0030823 regulation of cGMP metabolic process GO:0030828 positive regulation of cGMP biosynthetic process GO:0040014 regulation of multicellular organism growth GO:0042493 response to drug GO:0045471 response to ethanol GO:0045669 positive regulation of osteoblast differentiation GO:0048513 animal organ development GO:0048660 regulation of smooth muscle cell proliferation GO:0050880 regulation of blood vessel size GO:0051053 negative regulation of DNA metabolic process GO:0051447 negative regulation of meiotic cell cycle GO:1900194 negative regulation of oocyte maturation GO:1903779 regulation of cardiac conduction