Human Gene ID1 (ENST00000376112.4) from GENCODE V44
Description: Homo sapiens inhibitor of DNA binding 1, HLH protein (ID1), transcript variant 1, mRNA. (from RefSeq NM_002165) RefSeq Summary (NM_002165): The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000376112.4 Gencode Gene: ENSG00000125968.9 Transcript (Including UTRs) Position: hg38 chr20:31,605,289-31,606,510 Size: 1,222 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr20:31,605,388-31,606,094 Size: 707 Coding Exon Count: 2
ID:ID1_HUMAN DESCRIPTION: RecName: Full=DNA-binding protein inhibitor ID-1; AltName: Full=Class B basic helix-loop-helix protein 24; Short=bHLHb24; AltName: Full=Inhibitor of DNA binding 1; FUNCTION: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. SUBUNIT: Heterodimer with other HLH proteins. Interacts with COPS5 (By similarity). INTERACTION: O14936:CASK; NbExp=3; IntAct=EBI-1215527, EBI-1215506; Q03135:CAV1; NbExp=6; IntAct=EBI-1215527, EBI-603614; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. DEVELOPMENTAL STAGE: Expression correlates with proliferation in some types of cells. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41134
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
