Human Gene BPIFB1 (uc002wyw.1) Description and Page Index
Description: Homo sapiens BPI fold containing family B, member 1 (BPIFB1), mRNA. RefSeq Summary (NM_033197): The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008429.1, AF364078.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000253354.2/ ENSP00000253354.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr20:31,870,941-31,897,684 Size: 26,744 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr20:31,873,880-31,897,573 Size: 23,694 Coding Exon Count: 15
ID:BPIB1_HUMAN DESCRIPTION: RecName: Full=BPI fold-containing family B member 1; AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 1; AltName: Full=Von Ebner minor salivary gland protein; Short=VEMSGP; Flags: Precursor; FUNCTION: May play a role in innate immunity in mouth, nose and lungs. SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Detected in trachea, nasal septal epithelium and lung. SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TDL5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.