Human Gene TP53TG5 (ENST00000372726.5) from GENCODE V44
  Description: Homo sapiens TP53 target 5 (TP53TG5), mRNA. (from RefSeq NM_014477)
Gencode Transcript: ENST00000372726.5
Gencode Gene: ENSG00000124251.11
Transcript (Including UTRs)
   Position: hg38 chr20:45,372,557-45,378,325 Size: 5,769 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr20:45,373,907-45,378,236 Size: 4,330 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:45,372,557-45,378,325)mRNA (may differ from genome)Protein (290 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T53G5_HUMAN
DESCRIPTION: RecName: Full=TP53-target gene 5 protein; AltName: Full=TP53-inducible gene 5 protein;
FUNCTION: May play a significant role in p53/TP53-mediating signaling pathway.
SUBUNIT: Interacts with p53/TP53.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cell cycle dependent intracellular localization.
TISSUE SPECIFICITY: Highly expressed in heart, brain and small intestine. Less abundant in skeletal muscle, spleen, prostate, ovary and colon. A smaller transcript is expressed specifically in the testis.
INDUCTION: By p53/TP53, UV irradiation, by hydrogen peroxide treatment or by treatment with a DNA-damaging reagent.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.26 RPKM in Testis
Total median expression: 47.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.6089-0.299 Picture PostScript Text
3' UTR -506.001350-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9Y2B4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0030308 negative regulation of cell growth
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK295308 - Homo sapiens cDNA FLJ60547 complete cds, highly similar to TP53-target gene 5 protein.
BC036785 - Homo sapiens TP53 target 5, mRNA (cDNA clone MGC:46104 IMAGE:5744881), complete cds.
AB017802 - Homo sapiens mRNA for clg01, complete cds.
KJ893628 - Synthetic construct Homo sapiens clone ccsbBroadEn_03022 TP53TG5 gene, encodes complete protein.
CU691416 - Synthetic construct Homo sapiens gateway clone IMAGE:100016662 5' read C20orf10 mRNA.
JD464207 - Sequence 445231 from Patent EP1572962.
JD221119 - Sequence 202143 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C20orf10, ENST00000372726.1, ENST00000372726.2, ENST00000372726.3, ENST00000372726.4, NM_014477, Q9Y2B4, T53G5_HUMAN, uc002xny.1, uc002xny.2, uc002xny.3, uc002xny.4, uc002xny.5
UCSC ID: ENST00000372726.5
RefSeq Accession: NM_014477
Protein: Q9Y2B4 (aka T53G5_HUMAN or TPG5_HUMAN)
CCDS: CCDS13352.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.