ID:T53G5_HUMAN DESCRIPTION: RecName: Full=TP53-target gene 5 protein; AltName: Full=TP53-inducible gene 5 protein; FUNCTION: May play a significant role in p53/TP53-mediating signaling pathway. SUBUNIT: Interacts with p53/TP53. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cell cycle dependent intracellular localization. TISSUE SPECIFICITY: Highly expressed in heart, brain and small intestine. Less abundant in skeletal muscle, spleen, prostate, ovary and colon. A smaller transcript is expressed specifically in the testis. INDUCTION: By p53/TP53, UV irradiation, by hydrogen peroxide treatment or by treatment with a DNA-damaging reagent.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9Y2B4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.