Human Gene TPD52L2 (ENST00000217121.9)
  Description: Homo sapiens TPD52 like 2 (TPD52L2), transcript variant 1, mRNA. (from RefSeq NM_199360)
RefSeq Summary (NM_199360): This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000217121.9
Gencode Gene: ENSG00000101150.18
Transcript (Including UTRs)
   Position: hg38 chr20:63,865,294-63,891,545 Size: 26,252 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr20:63,865,366-63,889,945 Size: 24,580 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:63,865,294-63,891,545)mRNA (may differ from genome)Protein (229 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TPD54_HUMAN
DESCRIPTION: RecName: Full=Tumor protein D54; Short=hD54; AltName: Full=Tumor protein D52-like 2;
SUBUNIT: Forms homodimer or heterodimer with other members of the family (By similarity). Interacts with MAL2.
INTERACTION: Q62393:Tpd52 (xeno); NbExp=2; IntAct=EBI-782616, EBI-782591;
SIMILARITY: Belongs to the TPD52 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: TPD52L2
Diseases sorted by gene-association score: breast cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 77.30 RPKM in Cells - Cultured fibroblasts
Total median expression: 2672.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.4072-0.422 Picture PostScript Text
3' UTR -563.001600-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007327 - TPD52

Pfam Domains:
PF04201 - Tumour protein D52 family

ModBase Predicted Comparative 3D Structure on O43399
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0042127 regulation of cell proliferation

Cellular Component:
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK298366 - Homo sapiens cDNA FLJ53635 complete cds, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 6, mRNA.
AK055068 - Homo sapiens cDNA FLJ30506 fis, clone BRAWH2000522, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 4, mRNA.
AK314501 - Homo sapiens cDNA, FLJ95317, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), mRNA.
AK297064 - Homo sapiens cDNA FLJ54053 complete cds, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 6, mRNA.
AF004430 - Homo sapiens hD54+ins2 isoform (hD54) mRNA, complete cds.
JD125416 - Sequence 106440 from Patent EP1572962.
AK223031 - Homo sapiens mRNA for tumor protein D52-like 2 isoform e variant, clone: JTH06723.
AK293349 - Homo sapiens cDNA FLJ52530 complete cds, highly similar to Tumor protein D54.
CR749208 - Homo sapiens mRNA; cDNA DKFZp686A1765 (from clone DKFZp686A1765).
BC006804 - Homo sapiens tumor protein D52-like 2, mRNA (cDNA clone MGC:5064 IMAGE:3446037), complete cds.
AY323819 - Homo sapiens HCCR-binding protein 2 mRNA, complete cds.
DQ894300 - Synthetic construct Homo sapiens clone IMAGE:100008760; FLH169490.01L; RZPDo839C1295D tumor protein D52-like 2 (TPD52L2) gene, encodes complete protein.
KJ892305 - Synthetic construct Homo sapiens clone ccsbBroadEn_01699 TPD52L2 gene, encodes complete protein.
CU675461 - Synthetic construct Homo sapiens gateway clone IMAGE:100020634 5' read TPD52L2 mRNA.
DQ891121 - Synthetic construct clone IMAGE:100003751; FLH169494.01X; RZPDo839C1296D tumor protein D52-like 2 (TPD52L2) gene, encodes complete protein.
BT019631 - Homo sapiens tumor protein D52-like 2 mRNA, complete cds.
CR542036 - Homo sapiens full open reading frame cDNA clone RZPDo834H1235D for gene TPD52L2, tumor protein D52-like 2; complete cds, incl. stopcodon.
AB062396 - Homo sapiens OK/SW-cl.69 mRNA for tumor protein D52-like 2, complete cds.
AF004429 - Homo sapiens D54 isoform (hD54) mRNA, partial cds.
AK128744 - Homo sapiens cDNA FLJ44665 fis, clone BRACE3004371.
AK125709 - Homo sapiens cDNA FLJ43721 fis, clone TESOP2006893.
DQ591149 - Homo sapiens piRNA piR-58261, complete sequence.
JD103841 - Sequence 84865 from Patent EP1572962.
JD097722 - Sequence 78746 from Patent EP1572962.
JD131683 - Sequence 112707 from Patent EP1572962.
JD069348 - Sequence 50372 from Patent EP1572962.
JD142317 - Sequence 123341 from Patent EP1572962.
JD210921 - Sequence 191945 from Patent EP1572962.
JD564982 - Sequence 546006 from Patent EP1572962.
JD318317 - Sequence 299341 from Patent EP1572962.
JD242228 - Sequence 223252 from Patent EP1572962.
JD532068 - Sequence 513092 from Patent EP1572962.
JD420687 - Sequence 401711 from Patent EP1572962.
JD326780 - Sequence 307804 from Patent EP1572962.
JD150487 - Sequence 131511 from Patent EP1572962.
JD360278 - Sequence 341302 from Patent EP1572962.
JD381953 - Sequence 362977 from Patent EP1572962.
JD085918 - Sequence 66942 from Patent EP1572962.
JD301819 - Sequence 282843 from Patent EP1572962.
JD039164 - Sequence 20188 from Patent EP1572962.
JD174106 - Sequence 155130 from Patent EP1572962.
JD434477 - Sequence 415501 from Patent EP1572962.
JD307378 - Sequence 288402 from Patent EP1572962.
JD121423 - Sequence 102447 from Patent EP1572962.
JD115141 - Sequence 96165 from Patent EP1572962.
JD275152 - Sequence 256176 from Patent EP1572962.
JD408212 - Sequence 389236 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E1P5G7, ENST00000217121.1, ENST00000217121.2, ENST00000217121.3, ENST00000217121.4, ENST00000217121.5, ENST00000217121.6, ENST00000217121.7, ENST00000217121.8, NM_199360, O43398, O43399, Q5JWU5, Q5JWU8, Q5U0E0, Q9H3Z6, TPD54_HUMAN, uc002ygy.1, uc002ygy.2, uc002ygy.3, uc002ygy.4
UCSC ID: ENST00000217121.9
RefSeq Accession: NM_199360
Protein: O43399 (aka TPD54_HUMAN)
CCDS: CCDS13542.1, CCDS13544.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.