Human Gene TPD52L2 (ENST00000217121.9)
  Description: Homo sapiens TPD52 like 2 (TPD52L2), transcript variant 1, mRNA. (from RefSeq NM_199360)
RefSeq Summary (NM_199360): This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000217121.9
Gencode Gene: ENSG00000101150.18
Transcript (Including UTRs)
   Position: hg38 chr20:63,865,294-63,891,545 Size: 26,252 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr20:63,865,366-63,889,945 Size: 24,580 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:63,865,294-63,891,545)mRNA (may differ from genome)Protein (229 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tumor protein D54; Short=hD54; AltName: Full=Tumor protein D52-like 2;
SUBUNIT: Forms homodimer or heterodimer with other members of the family (By similarity). Interacts with MAL2.
INTERACTION: Q62393:Tpd52 (xeno); NbExp=2; IntAct=EBI-782616, EBI-782591;
SIMILARITY: Belongs to the TPD52 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: TPD52L2
Diseases sorted by gene-association score: breast cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 77.30 RPKM in Cells - Cultured fibroblasts
Total median expression: 2672.40 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.4072-0.422 Picture PostScript Text
3' UTR -563.001600-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007327 - TPD52

Pfam Domains:
PF04201 - Tumour protein D52 family

ModBase Predicted Comparative 3D Structure on O43399
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0042127 regulation of cell proliferation

Cellular Component:
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm

-  Descriptions from all associated GenBank mRNAs
  AK298366 - Homo sapiens cDNA FLJ53635 complete cds, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 6, mRNA.
AK055068 - Homo sapiens cDNA FLJ30506 fis, clone BRAWH2000522, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 4, mRNA.
AK314501 - Homo sapiens cDNA, FLJ95317, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), mRNA.
AK297064 - Homo sapiens cDNA FLJ54053 complete cds, highly similar to Homo sapiens tumor protein D52-like 2 (TPD52L2), transcript variant 6, mRNA.
AF004430 - Homo sapiens hD54+ins2 isoform (hD54) mRNA, complete cds.
JD125416 - Sequence 106440 from Patent EP1572962.
AK223031 - Homo sapiens mRNA for tumor protein D52-like 2 isoform e variant, clone: JTH06723.
AK293349 - Homo sapiens cDNA FLJ52530 complete cds, highly similar to Tumor protein D54.
CR749208 - Homo sapiens mRNA; cDNA DKFZp686A1765 (from clone DKFZp686A1765).
BC006804 - Homo sapiens tumor protein D52-like 2, mRNA (cDNA clone MGC:5064 IMAGE:3446037), complete cds.
AY323819 - Homo sapiens HCCR-binding protein 2 mRNA, complete cds.
DQ894300 - Synthetic construct Homo sapiens clone IMAGE:100008760; FLH169490.01L; RZPDo839C1295D tumor protein D52-like 2 (TPD52L2) gene, encodes complete protein.
KJ892305 - Synthetic construct Homo sapiens clone ccsbBroadEn_01699 TPD52L2 gene, encodes complete protein.
CU675461 - Synthetic construct Homo sapiens gateway clone IMAGE:100020634 5' read TPD52L2 mRNA.
DQ891121 - Synthetic construct clone IMAGE:100003751; FLH169494.01X; RZPDo839C1296D tumor protein D52-like 2 (TPD52L2) gene, encodes complete protein.
BT019631 - Homo sapiens tumor protein D52-like 2 mRNA, complete cds.
CR542036 - Homo sapiens full open reading frame cDNA clone RZPDo834H1235D for gene TPD52L2, tumor protein D52-like 2; complete cds, incl. stopcodon.
AB062396 - Homo sapiens OK/SW-cl.69 mRNA for tumor protein D52-like 2, complete cds.
AF004429 - Homo sapiens D54 isoform (hD54) mRNA, partial cds.
AK128744 - Homo sapiens cDNA FLJ44665 fis, clone BRACE3004371.
AK125709 - Homo sapiens cDNA FLJ43721 fis, clone TESOP2006893.
DQ591149 - Homo sapiens piRNA piR-58261, complete sequence.
JD103841 - Sequence 84865 from Patent EP1572962.
JD097722 - Sequence 78746 from Patent EP1572962.
JD131683 - Sequence 112707 from Patent EP1572962.
JD069348 - Sequence 50372 from Patent EP1572962.
JD142317 - Sequence 123341 from Patent EP1572962.
JD210921 - Sequence 191945 from Patent EP1572962.
JD564982 - Sequence 546006 from Patent EP1572962.
JD318317 - Sequence 299341 from Patent EP1572962.
JD242228 - Sequence 223252 from Patent EP1572962.
JD532068 - Sequence 513092 from Patent EP1572962.
JD420687 - Sequence 401711 from Patent EP1572962.
JD326780 - Sequence 307804 from Patent EP1572962.
JD150487 - Sequence 131511 from Patent EP1572962.
JD360278 - Sequence 341302 from Patent EP1572962.
JD381953 - Sequence 362977 from Patent EP1572962.
JD085918 - Sequence 66942 from Patent EP1572962.
JD301819 - Sequence 282843 from Patent EP1572962.
JD039164 - Sequence 20188 from Patent EP1572962.
JD174106 - Sequence 155130 from Patent EP1572962.
JD434477 - Sequence 415501 from Patent EP1572962.
JD307378 - Sequence 288402 from Patent EP1572962.
JD121423 - Sequence 102447 from Patent EP1572962.
JD115141 - Sequence 96165 from Patent EP1572962.
JD275152 - Sequence 256176 from Patent EP1572962.
JD408212 - Sequence 389236 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E1P5G7, ENST00000217121.1, ENST00000217121.2, ENST00000217121.3, ENST00000217121.4, ENST00000217121.5, ENST00000217121.6, ENST00000217121.7, ENST00000217121.8, NM_199360, O43398, O43399, Q5JWU5, Q5JWU8, Q5U0E0, Q9H3Z6, TPD54_HUMAN, uc002ygy.1, uc002ygy.2, uc002ygy.3, uc002ygy.4
UCSC ID: ENST00000217121.9
RefSeq Accession: NM_199360
Protein: O43399 (aka TPD54_HUMAN)
CCDS: CCDS13542.1, CCDS13544.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.