Human Gene LIPI (ENST00000344577.6) from GENCODE V44
  Description: lipase I (from HGNC LIPI)
RefSeq Summary (NM_198996): The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gencode Transcript: ENST00000344577.6
Gencode Gene: ENSG00000188992.12
Transcript (Including UTRs)
   Position: hg38 chr21:14,108,813-14,206,949 Size: 98,137 Total Exon Count: 10 Strand: -


Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:14,108,813-14,206,949)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGencodeHGNCLynxMalacardsPubMed

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LIPI
Diseases sorted by gene-association score: hypertriglyceridemia* (986), listeriosis (6), cardiac tamponade (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.76 RPKM in Thyroid
Total median expression: 4.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AY197607 - Homo sapiens membrane-associated phospholipase A1 beta mRNA, complete cds.
JN387910 - Homo sapiens membrane-associated phospholipase A1 beta fl (LIPI) mRNA, complete cds, alternatively spliced.
JN387911 - Homo sapiens membrane-associated phospholipase A1 beta 7B+ (LIPI) mRNA, complete cds, alternatively spliced.
JN387912 - Homo sapiens membrane-associated phospholipase A1 beta deltaE2-3 (LIPI) mRNA, complete cds, alternatively spliced.
JN387913 - Homo sapiens membrane-associated phospholipase A1 beta deltaE5 (LIPI) mRNA, complete cds, alternatively spliced.
JN387914 - Homo sapiens membrane-associated phospholipase A1 beta deltaE6.1 (LIPI) mRNA, complete cds, alternatively spliced.
JN387915 - Homo sapiens membrane-associated phospholipase A1 beta deltaE7.2 (LIPI) mRNA, complete cds, alternatively spliced.
JN387916 - Homo sapiens membrane-associated phospholipase A1 beta deltaE8-9 (LIPI) mRNA, complete cds, alternatively spliced.
BC148691 - Synthetic construct Homo sapiens clone IMAGE:100015651, MGC:183143 lipase, member I (LIPI) mRNA, encodes complete protein.
BC140336 - Synthetic construct Homo sapiens clone IMAGE:100014321, MGC:173197 lipase, member I (LIPI) mRNA, encodes complete protein.
AB463838 - Synthetic construct DNA, clone: pF1KB7237, Homo sapiens LIPI gene for lipase, member I, without stop codon, in Flexi system.
JD175122 - Sequence 156146 from Patent EP1572962.
JD204294 - Sequence 185318 from Patent EP1572962.
AY918476 - Homo sapiens membrane-associated phospholipase A1 beta splice variant (LOC375108) mRNA, partial cds, alternatively spliced.

-  Other Names for This Gene
  Alternate Gene Symbols: AY197607, ENST00000344577.1, ENST00000344577.2, ENST00000344577.3, ENST00000344577.4, ENST00000344577.5, uc002yjm.1, uc002yjm.2, uc002yjm.3, uc002yjm.4
UCSC ID: ENST00000344577.6
RefSeq Accession: NM_198996
CCDS: CCDS13564.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.