ID:KR241_HUMAN DESCRIPTION: RecName: Full=Keratin-associated protein 24-1; FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. SUBUNIT: Interacts with hair keratins (By similarity). TISSUE SPECIFICITY: Specific expression in the middle/upper hair cuticle. MISCELLANEOUS: Has a low cysteine content when compared to the majority of known KAP family members. Possesses several C-terminal tyrosine-containing tandem decameric repeat structures. SIMILARITY: Belongs to the PMG family. CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3LI83
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AM238513 - Homo sapiens mRNA for hair keratin associated protein (krtap24-1 gene). AB096935 - Homo sapiens KRTAP24-1 mRNA for keratin associated protein, complete cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q3LI83 (Reactome details) participates in the following event(s):
US Server
