Human Gene CRYZL1 (ENST00000420072.5) from GENCODE V44
  Description: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95825-1; Sequence=Displayed; Name=2; IsoId=O95825-2; Sequence=Not described; Note=No experimental confirmation available; (from UniProt O95825)
RefSeq Summary (NM_145858): This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000420072.5
Gencode Gene: ENSG00000205758.12
Transcript (Including UTRs)
   Position: hg38 chr21:33,594,662-33,642,338 Size: 47,677 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr21:33,599,266-33,631,551 Size: 32,286 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:33,594,662-33,642,338)mRNA (may differ from genome)Protein (198 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: QORL1_HUMAN
DESCRIPTION: RecName: Full=Quinone oxidoreductase-like protein 1; EC=1.-.-.-; AltName: Full=Protein 4P11; AltName: Full=Quinone oxidoreductase homolog 1; Short=QOH-1; AltName: Full=Zeta-crystallin homolog;
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
SEQUENCE CAUTION: Sequence=AAH13155.1; Type=Miscellaneous discrepancy; Sequence=BAA91605.1; Type=Frameshift; Positions=302;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CRYZL1
Diseases sorted by gene-association score: retinitis pigmentosa 3 (5), norrie disease (5), exudative vitreoretinopathy (4), congenital stationary night blindness (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.50 RPKM in Testis
Total median expression: 281.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -253.70664-0.382 Picture PostScript Text
3' UTR -338.601297-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013149 - ADH_C
IPR013154 - ADH_GroES-like
IPR002085 - ADH_SF_Zn-type
IPR011032 - GroES-like
IPR016040 - NAD(P)-bd_dom

Pfam Domains:
PF08240 - Alcohol dehydrogenase GroES-like domain
PF00107 - Zinc-binding dehydrogenase

ModBase Predicted Comparative 3D Structure on O95825
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003960 NADPH:quinone reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding

Biological Process:
GO:0055114 oxidation-reduction process
GO:1901661 quinone metabolic process

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AL157441 - Homo sapiens mRNA; cDNA DKFZp434M035 (from clone DKFZp434M035).
BC033023 - Homo sapiens crystallin, zeta (quinone reductase)-like 1, mRNA (cDNA clone MGC:32911 IMAGE:5269248), complete cds.
LF385147 - JP 2014500723-A/192650: Polycomb-Associated Non-Coding RNAs.
MA620724 - JP 2018138019-A/192650: Polycomb-Associated Non-Coding RNAs.
AK001293 - Homo sapiens cDNA FLJ10431 fis, clone NT2RP1000443, weakly similar to QUINONE OXIDOREDUCTASE (EC 1.6.5.5).
AK058071 - Homo sapiens cDNA FLJ25342 fis, clone TST01018.
AF029689 - Homo sapiens quinone oxidoreductase homolog-1 mRNA, complete cds.
AF098798 - Homo sapiens unknown mRNA.
AK315707 - Homo sapiens cDNA, FLJ96806, Homo sapiens crystallin, zeta (quinone reductase)-like 1 (CRYZL1),transcript variant 1, mRNA.
DQ891009 - Synthetic construct clone IMAGE:100003639; FLH168495.01X; RZPDo839H0892D crystallin, zeta (quinone reductase)-like 1 (CRYZL1) gene, encodes complete protein.
DQ894190 - Synthetic construct Homo sapiens clone IMAGE:100008650; FLH168491.01L; RZPDo839H0891D crystallin, zeta (quinone reductase)-like 1 (CRYZL1) gene, encodes complete protein.
BC039589 - Homo sapiens, clone IMAGE:4453454, mRNA.
BX647276 - Homo sapiens mRNA; cDNA DKFZp686B0193 (from clone DKFZp686B0193).
BX648547 - Homo sapiens mRNA; cDNA DKFZp779H2066 (from clone DKFZp779H2066).
AK057604 - Homo sapiens cDNA FLJ33042 fis, clone THYMU2000436, highly similar to Quinone oxidoreductase-like 1 (EC 1.-.-.-).
JD534697 - Sequence 515721 from Patent EP1572962.
JD292508 - Sequence 273532 from Patent EP1572962.
JD092074 - Sequence 73098 from Patent EP1572962.
JD183898 - Sequence 164922 from Patent EP1572962.
JD066619 - Sequence 47643 from Patent EP1572962.
JD309261 - Sequence 290285 from Patent EP1572962.
JD361171 - Sequence 342195 from Patent EP1572962.
JD080894 - Sequence 61918 from Patent EP1572962.
JD322957 - Sequence 303981 from Patent EP1572962.
JD307079 - Sequence 288103 from Patent EP1572962.
JD434905 - Sequence 415929 from Patent EP1572962.
JD529700 - Sequence 510724 from Patent EP1572962.
JD173106 - Sequence 154130 from Patent EP1572962.
JD203434 - Sequence 184458 from Patent EP1572962.
JD539871 - Sequence 520895 from Patent EP1572962.
JD178999 - Sequence 160023 from Patent EP1572962.
JD430468 - Sequence 411492 from Patent EP1572962.
JD395428 - Sequence 376452 from Patent EP1572962.
JD277274 - Sequence 258298 from Patent EP1572962.
JD425060 - Sequence 406084 from Patent EP1572962.
JD165408 - Sequence 146432 from Patent EP1572962.
JD401615 - Sequence 382639 from Patent EP1572962.
JD047614 - Sequence 28638 from Patent EP1572962.
JD238370 - Sequence 219394 from Patent EP1572962.
JD047615 - Sequence 28639 from Patent EP1572962.
JD238371 - Sequence 219395 from Patent EP1572962.
JD426859 - Sequence 407883 from Patent EP1572962.
JD135795 - Sequence 116819 from Patent EP1572962.
JD052727 - Sequence 33751 from Patent EP1572962.
JD225872 - Sequence 206896 from Patent EP1572962.
JD348224 - Sequence 329248 from Patent EP1572962.
JD499202 - Sequence 480226 from Patent EP1572962.
JD434813 - Sequence 415837 from Patent EP1572962.
JD305175 - Sequence 286199 from Patent EP1572962.
JD539457 - Sequence 520481 from Patent EP1572962.
JD242471 - Sequence 223495 from Patent EP1572962.
AF086550 - Homo sapiens full length insert cDNA clone ZE12F12.
LF339921 - JP 2014500723-A/147424: Polycomb-Associated Non-Coding RNAs.
MA575498 - JP 2018138019-A/147424: Polycomb-Associated Non-Coding RNAs.
JD171844 - Sequence 152868 from Patent EP1572962.
JD404154 - Sequence 385178 from Patent EP1572962.
JD182104 - Sequence 163128 from Patent EP1572962.
JD149118 - Sequence 130142 from Patent EP1572962.
JD233682 - Sequence 214706 from Patent EP1572962.
JD279438 - Sequence 260462 from Patent EP1572962.
JD449242 - Sequence 430266 from Patent EP1572962.
JD350487 - Sequence 331511 from Patent EP1572962.
LF339924 - JP 2014500723-A/147427: Polycomb-Associated Non-Coding RNAs.
MA575501 - JP 2018138019-A/147427: Polycomb-Associated Non-Coding RNAs.
LF339925 - JP 2014500723-A/147428: Polycomb-Associated Non-Coding RNAs.
MA575502 - JP 2018138019-A/147428: Polycomb-Associated Non-Coding RNAs.
BC013155 - Homo sapiens crystallin, zeta (quinone reductase)-like 1, mRNA (cDNA clone IMAGE:3870188), complete cds.
KJ902042 - Synthetic construct Homo sapiens clone ccsbBroadEn_11436 CRYZL1 gene, encodes complete protein.
CU680532 - Synthetic construct Homo sapiens gateway clone IMAGE:100016675 5' read CRYZL1 mRNA.
BC022827 - Homo sapiens crystallin, zeta (quinone reductase)-like 1, mRNA (cDNA clone IMAGE:3632782), partial cds.
JD044324 - Sequence 25348 from Patent EP1572962.
JD539410 - Sequence 520434 from Patent EP1572962.
LF339932 - JP 2014500723-A/147435: Polycomb-Associated Non-Coding RNAs.
MA575509 - JP 2018138019-A/147435: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: 4P11, AK057604, B2RDX1, ENST00000420072.1, ENST00000420072.2, ENST00000420072.3, ENST00000420072.4, O95825, Q96DY0, Q9NVY7, QORL1_HUMAN, uc002yss.1, uc002yss.2
UCSC ID: ENST00000420072.5
RefSeq Accession: NM_145858
Protein: O95825 (aka QORL1_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.