Human Gene RCAN1 (ENST00000381132.6) from GENCODE V44
Description: Homo sapiens regulator of calcineurin 1 (RCAN1), transcript variant 3, mRNA. (from RefSeq NM_203418) RefSeq Summary (NM_203418): The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]. Gencode Transcript: ENST00000381132.6 Gencode Gene: ENSG00000159200.18 Transcript (Including UTRs) Position: hg38 chr21:34,516,484-34,526,963 Size: 10,480 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr21:34,518,084-34,526,749 Size: 8,666 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6FGP2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.