Human Gene GUCD1 (ENST00000407471.7) from GENCODE V44
  Description: Homo sapiens guanylyl cyclase domain containing 1 (GUCD1), transcript variant 4, mRNA. (from RefSeq NM_031444)
Gencode Transcript: ENST00000407471.7
Gencode Gene: ENSG00000138867.17
Transcript (Including UTRs)
   Position: hg38 chr22:24,540,438-24,555,182 Size: 14,745 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr22:24,543,006-24,554,991 Size: 11,986 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:24,540,438-24,555,182)mRNA (may differ from genome)Protein (240 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CV013_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C22orf13; AltName: Full=Protein LLN4;
SEQUENCE CAUTION: Sequence=BAB68411.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.02 RPKM in Small Intestine - Terminal Ileum
Total median expression: 1064.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -109.10191-0.571 Picture PostScript Text
3' UTR -1029.302568-0.401 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018616 - Guanylyl_cyclase

Pfam Domains:
PF09778 - Guanylylate cyclase

ModBase Predicted Comparative 3D Structure on Q96NT3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI  Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  BC004144 - Homo sapiens chromosome 22 open reading frame 13, mRNA (cDNA clone IMAGE:2819509).
AK024723 - Homo sapiens cDNA: FLJ21070 fis, clone CAS01707.
BC041568 - Homo sapiens chromosome 22 open reading frame 13, mRNA (cDNA clone IMAGE:3504340), partial cds.
AK025242 - Homo sapiens cDNA: FLJ21589 fis, clone COL06960.
BC015685 - Homo sapiens chromosome 22 open reading frame 13, mRNA (cDNA clone IMAGE:4650618), partial cds.
BC053529 - Homo sapiens chromosome 22 open reading frame 13, mRNA (cDNA clone IMAGE:3848564), partial cds.
BC070109 - Homo sapiens chromosome 22 open reading frame 13, mRNA (cDNA clone MGC:87632 IMAGE:4838028), complete cds.
BC002924 - Homo sapiens chromosome 22 open reading frame 13, mRNA (cDNA clone IMAGE:3956179), partial cds.
AK054681 - Homo sapiens cDNA FLJ30119 fis, clone BRACE1000070.
JD426081 - Sequence 407105 from Patent EP1572962.
JD338732 - Sequence 319756 from Patent EP1572962.
JD371821 - Sequence 352845 from Patent EP1572962.
JD377377 - Sequence 358401 from Patent EP1572962.
JD087384 - Sequence 68408 from Patent EP1572962.
JD324620 - Sequence 305644 from Patent EP1572962.
JD355764 - Sequence 336788 from Patent EP1572962.
JD099447 - Sequence 80471 from Patent EP1572962.
JD434372 - Sequence 415396 from Patent EP1572962.
JD550538 - Sequence 531562 from Patent EP1572962.
JD488749 - Sequence 469773 from Patent EP1572962.
JD278464 - Sequence 259488 from Patent EP1572962.
JD449048 - Sequence 430072 from Patent EP1572962.
KJ903352 - Synthetic construct Homo sapiens clone ccsbBroadEn_12746 C22orf13 gene, encodes complete protein.
JD155966 - Sequence 136990 from Patent EP1572962.
JD081004 - Sequence 62028 from Patent EP1572962.
JD493125 - Sequence 474149 from Patent EP1572962.
JD041621 - Sequence 22645 from Patent EP1572962.
JD169510 - Sequence 150534 from Patent EP1572962.
JD342204 - Sequence 323228 from Patent EP1572962.
JD522073 - Sequence 503097 from Patent EP1572962.
JD275970 - Sequence 256994 from Patent EP1572962.
JD466759 - Sequence 447783 from Patent EP1572962.
JD242676 - Sequence 223700 from Patent EP1572962.
JD262186 - Sequence 243210 from Patent EP1572962.
JD441655 - Sequence 422679 from Patent EP1572962.
JD266103 - Sequence 247127 from Patent EP1572962.
JD300610 - Sequence 281634 from Patent EP1572962.
JD266102 - Sequence 247126 from Patent EP1572962.
JD271487 - Sequence 252511 from Patent EP1572962.
JD474892 - Sequence 455916 from Patent EP1572962.
JD562905 - Sequence 543929 from Patent EP1572962.
JD475464 - Sequence 456488 from Patent EP1572962.
JD224838 - Sequence 205862 from Patent EP1572962.
JD270475 - Sequence 251499 from Patent EP1572962.
JD066188 - Sequence 47212 from Patent EP1572962.
JD382868 - Sequence 363892 from Patent EP1572962.
JD474786 - Sequence 455810 from Patent EP1572962.
JD466548 - Sequence 447572 from Patent EP1572962.
JD067182 - Sequence 48206 from Patent EP1572962.
JD479896 - Sequence 460920 from Patent EP1572962.
JD263863 - Sequence 244887 from Patent EP1572962.
JD469392 - Sequence 450416 from Patent EP1572962.
JD068914 - Sequence 49938 from Patent EP1572962.
JD317487 - Sequence 298511 from Patent EP1572962.
JD335726 - Sequence 316750 from Patent EP1572962.
JD115014 - Sequence 96038 from Patent EP1572962.
JD190895 - Sequence 171919 from Patent EP1572962.
JD051151 - Sequence 32175 from Patent EP1572962.
JD051150 - Sequence 32174 from Patent EP1572962.
AK098754 - Homo sapiens cDNA FLJ25888 fis, clone CBR03058.
JD355990 - Sequence 337014 from Patent EP1572962.
JD267846 - Sequence 248870 from Patent EP1572962.
JD489797 - Sequence 470821 from Patent EP1572962.
JD270864 - Sequence 251888 from Patent EP1572962.
JD231194 - Sequence 212218 from Patent EP1572962.
JD339158 - Sequence 320182 from Patent EP1572962.
JD199380 - Sequence 180404 from Patent EP1572962.
JD253268 - Sequence 234292 from Patent EP1572962.
JD384255 - Sequence 365279 from Patent EP1572962.
JD295806 - Sequence 276830 from Patent EP1572962.
JD372809 - Sequence 353833 from Patent EP1572962.
JD546005 - Sequence 527029 from Patent EP1572962.
JD190144 - Sequence 171168 from Patent EP1572962.
JD200512 - Sequence 181536 from Patent EP1572962.
AK296893 - Homo sapiens cDNA FLJ55093 complete cds.
JD452085 - Sequence 433109 from Patent EP1572962.
JD513688 - Sequence 494712 from Patent EP1572962.
AK294972 - Homo sapiens cDNA FLJ61115 complete cds.
JD465695 - Sequence 446719 from Patent EP1572962.
JD180586 - Sequence 161610 from Patent EP1572962.
JD539222 - Sequence 520246 from Patent EP1572962.
JD393190 - Sequence 374214 from Patent EP1572962.
JD254508 - Sequence 235532 from Patent EP1572962.
CU687038 - Synthetic construct Homo sapiens gateway clone IMAGE:100022770 5' read C22orf13 mRNA.
HQ447432 - Synthetic construct Homo sapiens clone IMAGE:100070759; CCSB014410_01 chromosome 22 open reading frame 13 (C22orf13) gene, encodes complete protein.
KJ903353 - Synthetic construct Homo sapiens clone ccsbBroadEn_12747 C22orf13 gene, encodes complete protein.
JD439193 - Sequence 420217 from Patent EP1572962.
JD442307 - Sequence 423331 from Patent EP1572962.
JD541621 - Sequence 522645 from Patent EP1572962.
JD060631 - Sequence 41655 from Patent EP1572962.
DQ600107 - Homo sapiens piRNA piR-38173, complete sequence.
JD204318 - Sequence 185342 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B5MCB8, C22orf13, CV013_HUMAN, ENST00000407471.1, ENST00000407471.2, ENST00000407471.3, ENST00000407471.4, ENST00000407471.5, ENST00000407471.6, LLN4, NM_031444, Q96NT3, Q96Q79, Q9BU32, uc003aah.1, uc003aah.2, uc003aah.3, uc003aah.4
UCSC ID: ENST00000407471.7
RefSeq Accession: NM_031444
Protein: Q96NT3 (aka CV013_HUMAN)
CCDS: CCDS33621.1, CCDS63426.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.