Human Gene KREMEN1 (ENST00000400335.9) from GENCODE V44
Description: Homo sapiens kringle containing transmembrane protein 1 (KREMEN1), transcript variant 3, mRNA. (from RefSeq NM_001039570) RefSeq Summary (NM_001039570): This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000400335.9 Gencode Gene: ENSG00000183762.13 Transcript (Including UTRs) Position: hg38 chr22:29,073,035-29,146,820 Size: 73,786 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr22:29,073,131-29,142,112 Size: 68,982 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96MU8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.