The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H1I8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0006307 DNA dealkylation involved in DNA repair GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated
BC032760 - Homo sapiens activating signal cointegrator 1 complex subunit 2, mRNA (cDNA clone IMAGE:3452507), with apparent retained intron. AL096741 - Homo sapiens mRNA; cDNA DKFZp586O0223 (from clone DKFZp586O0223). AK025241 - Homo sapiens cDNA: FLJ21588 fis, clone COL06949. AK222723 - Homo sapiens mRNA for activating signal cointegrator 1 complex subunit 2 variant, clone: COL06949. AK223033 - Homo sapiens mRNA for activating signal cointegrator 1 complex subunit 2 variant, clone: HUV01010. BC025368 - Homo sapiens activating signal cointegrator 1 complex subunit 2, mRNA (cDNA clone MGC:15020 IMAGE:3955747), complete cds. AY013289 - Homo sapiens ASC-1 complex subunit P100 mRNA, complete cds. AK022886 - Homo sapiens cDNA FLJ12824 fis, clone NT2RP2002753. JD285869 - Sequence 266893 from Patent EP1572962. JD049514 - Sequence 30538 from Patent EP1572962. JD176222 - Sequence 157246 from Patent EP1572962. JD064497 - Sequence 45521 from Patent EP1572962. JD197270 - Sequence 178294 from Patent EP1572962. JD255013 - Sequence 236037 from Patent EP1572962. JD088235 - Sequence 69259 from Patent EP1572962. JD319163 - Sequence 300187 from Patent EP1572962. AK303257 - Homo sapiens cDNA FLJ53441 complete cds, highly similar to Activating signal cointegrator 1 complex subunit 2. JD451613 - Sequence 432637 from Patent EP1572962. KJ894943 - Synthetic construct Homo sapiens clone ccsbBroadEn_04337 ASCC2 gene, encodes complete protein. AB590901 - Synthetic construct DNA, clone: pFN21AE2083, Homo sapiens ASCC2 gene for activating signal cointegrator 1 complex subunit 2, without stop codon, in Flexi system. JD141330 - Sequence 122354 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H1I8 (Reactome details) participates in the following event(s):
R-HSA-5657617 ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC R-HSA-5657637 ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA R-HSA-5657642 ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA R-HSA-112123 Oxidative demethylation of 1-meA damaged DNA By ALKBH3 R-HSA-112124 Oxidative demethylation of 3-meC damaged DNA By ALKBH3 R-HSA-112125 Oxidative dealkylation of 1-EtA damaged DNA by ABH3 R-HSA-112126 ALKBH3 mediated reversal of alkylation damage R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases R-HSA-73942 DNA Damage Reversal R-HSA-73894 DNA Repair
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
