Human Gene MTMR3 (ENST00000351488.7) from GENCODE V44
Description: Homo sapiens myotubularin related protein 3 (MTMR3), transcript variant 2, mRNA. (from RefSeq NM_153051) RefSeq Summary (NM_153051): This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000351488.7 Gencode Gene: ENSG00000100330.16 Transcript (Including UTRs) Position: hg38 chr22:29,883,213-30,026,495 Size: 143,283 Total Exon Count: 19 Strand: + Coding Region Position: hg38 chr22:29,971,060-30,025,801 Size: 54,742 Coding Exon Count: 17
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13615
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
