Human Gene CCDC134 (ENST00000255784.6) from GENCODE V44
  Description: Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 1, mRNA. (from RefSeq NM_024821)
Gencode Transcript: ENST00000255784.6
Gencode Gene: ENSG00000100147.14
Transcript (Including UTRs)
   Position: hg38 chr22:41,800,679-41,832,164 Size: 31,486 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr22:41,808,891-41,825,823 Size: 16,933 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:41,800,679-41,832,164)mRNA (may differ from genome)Protein (229 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CC134_HUMAN
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 134; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the UPF0388 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.42 RPKM in Adrenal Gland
Total median expression: 80.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.50104-0.303 Picture PostScript Text
3' UTR -2315.906341-0.365 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026321 - Coiled-coil_dom_con_pro_134

ModBase Predicted Comparative 3D Structure on Q9H6E4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein SequenceProtein Sequence Protein Sequence 
AlignmentAlignmentAlignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  JF432590 - Synthetic construct Homo sapiens clone IMAGE:100073827 coiled-coil domain containing 134 (CCDC134) gene, encodes complete protein.
KJ894750 - Synthetic construct Homo sapiens clone ccsbBroadEn_04144 CCDC134 gene, encodes complete protein.
AK299311 - Homo sapiens cDNA FLJ50180 complete cds.
AK026002 - Homo sapiens cDNA: FLJ22349 fis, clone HRC06310.
CR456484 - Homo sapiens dJ821D11.3 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ821D11.3).
BC017693 - Homo sapiens coiled-coil domain containing 134, mRNA (cDNA clone MGC:21013 IMAGE:4403280), complete cds.
AB528097 - Synthetic construct DNA, clone: pF1KE0514, Homo sapiens CCDC134 gene for coiled-coil domain containing 134, without stop codon, in Flexi system.
CU013322 - Homo sapiens dJ821D11.3, mRNA (cDNA clone IMAGE:100000196), complete cds, without stop codon, in Gateway system.
CU013034 - Homo sapiens dJ821D11.3, mRNA (cDNA clone IMAGE:100000292), complete cds, with stop codon, in Gateway system.
JD348588 - Sequence 329612 from Patent EP1572962.
JD164326 - Sequence 145350 from Patent EP1572962.
JD372797 - Sequence 353821 from Patent EP1572962.
DQ595315 - Homo sapiens piRNA piR-61427, complete sequence.
DQ578925 - Homo sapiens piRNA piR-47037, complete sequence.
DQ593328 - Homo sapiens piRNA piR-33440, complete sequence.
DQ575106 - Homo sapiens piRNA piR-43218, complete sequence.
DQ575469 - Homo sapiens piRNA piR-43581, complete sequence.
DQ574490 - Homo sapiens piRNA piR-42602, complete sequence.
JD181346 - Sequence 162370 from Patent EP1572962.
JD055802 - Sequence 36826 from Patent EP1572962.
JD217985 - Sequence 199009 from Patent EP1572962.
JD217986 - Sequence 199010 from Patent EP1572962.
JD471743 - Sequence 452767 from Patent EP1572962.
JD075008 - Sequence 56032 from Patent EP1572962.
JD453568 - Sequence 434592 from Patent EP1572962.
JD078740 - Sequence 59764 from Patent EP1572962.
JD468397 - Sequence 449421 from Patent EP1572962.
JD115341 - Sequence 96365 from Patent EP1572962.
JD471038 - Sequence 452062 from Patent EP1572962.
JD219773 - Sequence 200797 from Patent EP1572962.
JD493802 - Sequence 474826 from Patent EP1572962.
JD199012 - Sequence 180036 from Patent EP1572962.
JD466590 - Sequence 447614 from Patent EP1572962.
JD485373 - Sequence 466397 from Patent EP1572962.
JD207189 - Sequence 188213 from Patent EP1572962.
JD307802 - Sequence 288826 from Patent EP1572962.
JD323881 - Sequence 304905 from Patent EP1572962.
JD383521 - Sequence 364545 from Patent EP1572962.
JD335917 - Sequence 316941 from Patent EP1572962.
JD260679 - Sequence 241703 from Patent EP1572962.
DQ583025 - Homo sapiens piRNA piR-50137, complete sequence.
DQ583026 - Homo sapiens piRNA piR-50138, complete sequence.
DQ596940 - Homo sapiens piRNA piR-35006, complete sequence.
DQ573439 - Homo sapiens piRNA piR-41551, complete sequence.
DQ591300 - Homo sapiens piRNA piR-58412, complete sequence.
DQ600525 - Homo sapiens piRNA piR-38591, complete sequence.
AK124515 - Homo sapiens cDNA FLJ42524 fis, clone BRACE3001384.
DQ596709 - Homo sapiens piRNA piR-34775, complete sequence.
DQ572041 - Homo sapiens piRNA piR-40153, complete sequence.
DQ595347 - Homo sapiens piRNA piR-61459, complete sequence.
DQ588935 - Homo sapiens piRNA piR-56047, complete sequence.
DQ587478 - Homo sapiens piRNA piR-54590, complete sequence.
DQ578374 - Homo sapiens piRNA piR-46486, complete sequence.
DQ591320 - Homo sapiens piRNA piR-58432, complete sequence.
DQ570210 - Homo sapiens piRNA piR-30322, complete sequence.
DQ591048 - Homo sapiens piRNA piR-58160, complete sequence.
JD429466 - Sequence 410490 from Patent EP1572962.
JD551952 - Sequence 532976 from Patent EP1572962.
JD337524 - Sequence 318548 from Patent EP1572962.
JD508628 - Sequence 489652 from Patent EP1572962.
JD035676 - Sequence 16700 from Patent EP1572962.
JD059564 - Sequence 40588 from Patent EP1572962.
JD268815 - Sequence 249839 from Patent EP1572962.
DQ595611 - Homo sapiens piRNA piR-61723, complete sequence.
AK054703 - Homo sapiens cDNA FLJ30141 fis, clone BRACE2000148.
JD220893 - Sequence 201917 from Patent EP1572962.
JD489025 - Sequence 470049 from Patent EP1572962.
JD272956 - Sequence 253980 from Patent EP1572962.
JD341375 - Sequence 322399 from Patent EP1572962.
DQ600618 - Homo sapiens piRNA piR-38684, complete sequence.
DQ595155 - Homo sapiens piRNA piR-61267, complete sequence.
DQ598395 - Homo sapiens piRNA piR-36461, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: CC134_HUMAN, ENST00000255784.1, ENST00000255784.2, ENST00000255784.3, ENST00000255784.4, ENST00000255784.5, NM_024821, Q9H6E4, uc003bbh.1, uc003bbh.2, uc003bbh.3
UCSC ID: ENST00000255784.6
RefSeq Accession: NM_024821
Protein: Q9H6E4 (aka CC134_HUMAN)
CCDS: CCDS33654.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.